Photo-mediated ultrasound therapy (PUT) holds potential as a novel antivascular method. In this work, we applied PUT to precisely remove corneal neovascularization in a rabbit eye model. A stable corneal suture-induced corneal neovascularization model was established in rabbits. These rabbits were later treated by PUT or used as controls. The treatment outcomes were evaluated through red-free photography and fluorescein angiography along with histology and immunohistochemistry. The experimental results demonstrated that PUT shows promise in improving the management of eye diseases by delivering selective treatment to pathologic vessels with minimized side effects.
We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. In this work, via the experiments in a rabbit ear model in vivo, the feasibility of PUT in the treatment of cutaneous microvessels was explored. Both the short-term effects and the long-term effects up to 4 weeks post-treatment were quantitatively assessed by measuring the perfusion rates of the vessels after treatment, showing that a single PUT treatment could significantly reduce blood perfusion. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of cutaneous vascular lesions.
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