Prof. Tzu-Ming Liu Profile

Prof. Tzu-Ming Liu

Professor at Univ of Macau

SPIE Involvement:

Conference Program Committee | Author

Publications (27)

Proceedings Article | 13 March 2024 Presentation + Paper

Evaluate time-course pharmacodynamics in tumor organoid with stress-induced lipofuscin-like autofluorescence

Yinghan Yan, Tzu-Ming Liu

Proceedings Volume 12821, 1282106 (2024) https://doi.org/10.1117/12.3008730

KEYWORDS: Autofluorescence, Tumors, Cell death, Mode conditioning cables, Medicine, Chemotherapy, Cancer

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Proceedings Article | 13 March 2024 Presentation + Paper

Plasma fluorochromics for the diagnosis of acute mesenteric ischemia

Xueqin Wu, Lun-Zhang Guo, Yi-Hung Liu, Yun-Shiuan Leung, Hwan-Ching Tai, Tzung-Dau Wang, Yueh-Hsun Chuang, Chih-Hsueh Lin, Pi-Tai Chou, I-Rue Lai, Tzu-Ming Liu

Proceedings Volume 12822, 1282204 (2024) https://doi.org/10.1117/12.3000662

KEYWORDS: Plasma, Fluorescence, Ischemia, Fluorescence intensity, Blood, Injuries, Biological samples, Fluorophores, Blood pressure, Animals

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Proceedings Article | 13 March 2024 Presentation + Paper

Spatial fluorescent metabolomics in prediabetic adipose tissues

Liping Chen, Guihui Qin, Yuhong Liu, Moxin Li, Lidong Du, Weiming Zheng, Xiaoyan Wang, Tzu-Ming Liu

Proceedings Volume 12831, 128310D (2024) https://doi.org/10.1117/12.3000710

KEYWORDS: Adipose tissue, Mitochondria, Fluorescence lifetime imaging, Resistance, Lithium, Inflammation, Glucose, Fluorescence, Autofluorescence, Two photon excitation microscopy

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Proceedings Article | 2 March 2022 Presentation

Speed up the drug screening with stress-induced red autofluorescence

Yinghan Yan, Ling Li, Zhengying Gao, Fuqiang Xing, Kai Miao, Fangyuan Shao, Chu-Xia Deng, Leo Tsz on Lee, Tzu-Ming Liu

Proceedings Volume PC11971, PC119710K (2022) https://doi.org/10.1117/12.2608401

KEYWORDS: Tumors, Luminescence, Cell death, Mode conditioning cables, Medicine, Cancer, Breast

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Proceedings Article | 13 March 2019 Presentation

Third harmonic generation angiography with FeOOH nanoparticle (Conference Presentation)

Tzu-Ming Liu, Chien-Wei Lee, Cheng-Han Wu, Yuan Tsung Hsieh, Pei-Chun Wu, Yu-Chun Chuang, Chih-Chia Huang

Proceedings Volume 10892, 108920Y (2019) https://doi.org/10.1117/12.2508495

KEYWORDS: Harmonic generation, Angiography, Nanoparticles, Magnetic resonance imaging, Iron, Oxides, Catalysis, Magnetism, Luminescence, Photomedicine

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Proceedings Article | 14 March 2018 Presentation

Fiber-based 1150-nm femtosecond laser source for the label-free virtual optical biopsy (Conference Presentation)

Tzu-Ming Liu, Jing-Yu Huang, Lun-Zhang Guo, Jing-Zun Wang, Tse-Chung Li, Hsin-Jung Lee, Po-Kai Chiu, Lung-Han Peng

Proceedings Volume 10488, 1048803 (2018) https://doi.org/10.1117/12.2286768

KEYWORDS: Femtosecond phenomena, Microscopy, Harmonic generation, Fiber lasers, Biopsy, Second-harmonic generation, In vivo imaging, Confocal microscopy, Femtosecond fiber lasers, Nonlinear optics

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Proceedings Article | 14 March 2018 Presentation

The effect of mice strain and labeling on the interstitial vessel permeability of nanoparticles (Conference Presentation)

Lin-Jie Lin, Pei-Chun Wu, Tzu-Ming Liu

Proceedings Volume 10475, 1047506 (2018) https://doi.org/10.1117/12.2288776

KEYWORDS: Tissues, Nanoparticles, Tumors, Nanomedicine, Optical character recognition, Harmonic generation, Microscopy, Luminescence, Cancer, In vivo imaging

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SPIE Journal Paper | 8 March 2017 Open Access

Fiber-based 1150-nm femtosecond laser source for the minimally invasive harmonic generation microscopy

Jing-Yu Huang, Lun-Zhang Guo, Jing-Zun Wang, Tse-Chung Li, Hsin-Jung Lee, Po-Kai Chiu, Lung-Han Peng, Tzu-Ming Liu

JBO, Vol. 22, Issue 03, 036008, (March 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.3.036008

KEYWORDS: Femtosecond phenomena, Second-harmonic generation, Solitons, In vivo imaging, Fiber lasers, Femtosecond fiber lasers, Microscopy, Harmonic generation, Biopsy, Tissues

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Proceedings Article | 27 April 2016 Presentation

Investigate the variation in optical redox ratio of epicardial adipose tissue in patients with CAD through auto-fluorescence metabolic molecular image (Conference Presentation)

Lun-Zhang Guo, Tzung-Dau Wang, Jong-Wei Lin, Tzu-Ming Liu

Proceedings Volume 9711, 971114 (2016) https://doi.org/10.1117/12.2212606

KEYWORDS: Computer aided diagnosis and therapy, Tissue optics, Luminescence, Tissues, Arteries, Microscopes, Infrared imaging, Infrared radiation, Molecules, Digital imaging

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Proceedings Article | 26 April 2016 Presentation

Two-photon photodynamic properties of TBO-AuNR-in-shell nanoparticles (Conference Presentation)

Cheng-Han Wu, Chen-Sheng Yeh, Fong-Yu Cheng, Zen-Uong Tsai, Tzu-Ming Liu

Proceedings Volume 9694, 96940S (2016) https://doi.org/10.1117/12.2212229

KEYWORDS: Current controlled current source, Photodynamic therapy, Oxygen, Nanoparticles, Multiphoton microscopy, Optical microscopy, Microscopy, Femtosecond phenomena, Biomedical engineering, Tumor growth modeling

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Proceedings Article | 4 March 2013 Paper

Enhanced delivery of gold nanoparticles by acoustic cavitation for photoacoustic imaging and photothermal therapy

Yu-Hsin Wang, Ai-Ho Liao, Jia-Yu Lin, Cheng-Ru Lee, Cheng-Ham Wu, Tzu-Min Liu, Churng-Ren Wang, Pai-Chi Li

Proceedings Volume 8581, 858123 (2013) https://doi.org/10.1117/12.2005870

KEYWORDS: Gold, Ultrasonography, Nanoparticles, Cavitation, Tumors, Photoacoustic spectroscopy, Acoustic cavitation, Acoustics, In vitro testing, Nanorods

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Proceedings Article | 22 February 2013 Paper

Multi-color femtosecond source for simultaneous excitation of multiple fluorescent proteins in two-photon fluorescence microscopy

Ke Wang, Tzu-Ming Liu, Juwell Wu, Nicholas Horton, Charles Lin, Chris Xu

Proceedings Volume 8588, 85882I (2013) https://doi.org/10.1117/12.2000583

KEYWORDS: Femtosecond phenomena, Solitons, Absorption, Fluorescent proteins, Luminescence, Fiber lasers, Two photon excitation microscopy, Second-harmonic generation, Tissues, Melanoma

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Proceedings Article | 22 February 2013 Paper

Multiphoton imaging to distinguish grana and starch inside an intact leaf

Mei-Yu Chen, Guan-Yu Zhuo, Po-Fu Chen, Pei-Chun Wu, Tzu-Ming Liu, Shi-Wei Chu

Proceedings Volume 8588, 858822 (2013) https://doi.org/10.1117/12.2003075

KEYWORDS: Second-harmonic generation, Luminescence, Multiphoton microscopy, Harmonic generation, Photosynthesis, Microscopy, Signal generators, Tissues, Microscopes, Objectives

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Proceedings Article | 22 February 2013 Paper

Imaging leukocytes in vivo with third harmonic generation microscopy

Cheng-Kun Tsai, Chien-Kuo Chen, Yu-Shing Chen, Pei-Chun Wu, Tsung-Yuan Hsieh, Han-Wen Liu, Chiou-Yueh Yeh, Win-Li Lin, Jean-San Chia, Tzu-Ming Liu

Proceedings Volume 8588, 85881R (2013) https://doi.org/10.1117/12.2003809

KEYWORDS: In vivo imaging, Blood, Microscopy, Harmonic generation, Capillaries, Confocal microscopy, Luminescence, Imaging systems, Spleen, Femtosecond phenomena

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Proceedings Article | 2 February 2012 Paper

In vivo track the development of melanoma with the intrinsic third harmonic generation and two-photon fluorescence contrasts of melanin

Pei-Chun Wu, Yu-Shing Chen, Tsung-Yuan Hsieh, Han-Wen Liu, Wen-Li Lin, Tzu-Ming Liu

Proceedings Volume 8233, 82330O (2012) https://doi.org/10.1117/12.906682

KEYWORDS: Melanoma, Tumors, In vivo imaging, Cancer, Second-harmonic generation, Luminescence, Harmonic generation, Microscopy, Collagen, Ear

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Proceedings Article | 2 February 2012 Paper

Multiphoton fluorescence spectra and lifetimes of biliverdins and their protein-associated complex

Chin-Jie Huang, Cheng-Ham Wu, Tzu-Ming Liu

Proceedings Volume 8233, 82330P (2012) https://doi.org/10.1117/12.907725

KEYWORDS: Luminescence, Proteins, Cancer, Multiphoton fluorescence microscopy, Femtosecond phenomena, Glucose, Photons, Absorption, Signal detection, Fetus

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Proceedings Article | 11 February 2011 Paper

Diagnosing hepatocellular carcinoma with the intensity and the lifetime of two-photon red autofluorescences

Tzu-Ming Liu, Chien-Tai Hsieh, Yu-Shing Chen, Fu-Lien Huang, Hsin-Yi Huang, Wen-Jeng Lee, Chun-Ta Kung, Chi-Kuang Sun

Proceedings Volume 7903, 79032Z (2011) https://doi.org/10.1117/12.872690

KEYWORDS: Liver, Tissues, Luminescence, Microscopy, Multiphoton microscopy, Multiphoton fluorescence microscopy, Second-harmonic generation, Femtosecond phenomena, Diagnostics, Fluorescence lifetime imaging

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SPIE Journal Paper | 1 January 2009 Open Access

Selective imaging in second-harmonic-generation microscopy with anisotropic radiation

Shi-Wei Chu, Shih-Peng Tai, Tzu-Ming Liu, Chi-Kuang Sun, Chi-Hung Lin

JBO, Vol. 14, Issue 01, 010504, (January 2009) https://doi.org/10.1117/12.10.1117/1.3080722

KEYWORDS: Collagen, Second-harmonic generation, Tissues, Optical fibers, Microscopy, Proteins, Polarization, Luminescence, Signal processing, Tissue optics

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SPIE Journal Paper | 1 November 2008 Open Access

In vivo long-term continuous observation of gene expression in zebrafish embryo nerve systems by using harmonic generation microscopy and morphant technology

Cho-Shuen Hsieh, Ching-Yi Ko, Szu-Yu Chen, Tzu-Ming Liu, Jian-Shiung Wu, Chin-Hwa Hu, Chi-Kuang Sun

JBO, Vol. 13, Issue 06, 064041, (November 2008) https://doi.org/10.1117/12.10.1117/1.3050423

KEYWORDS: Nerve, Second-harmonic generation, In vivo imaging, Molybdenum, Optical fibers, Nervous system, Microscopy, Harmonic generation, Luminescence, Proteins

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Proceedings Article | 14 February 2008 Paper

Resonant-enhanced dipolar interaction between THz-photons and confined acoustic phonons in nanostructures

Tzu-Ming Liu, Ja-Yu Lu, Chung-Chiu Kuo, Meng-Ju Yang, Chih-Wei Lai, Pi-Tai Chou, Ming-Hao Chang, Hsiang-Lin Liu, Yu-Tai Li, Ci-Ling Pan, Shih-Hung Lin, Chieh-Hsiung Kuan, Chi-Kuang Sun

Proceedings Volume 6892, 68921C (2008) https://doi.org/10.1117/12.760547

KEYWORDS: Terahertz radiation, Nanocrystals, Absorption, Acoustics, Phonons, FT-IR spectroscopy, Particles, Solids, Dielectrics, Spectroscopy

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Proceedings Article | 15 February 2006 Paper

GHz repetition-rate femtosecond sources with desired repetition-rate and wavelength

Tzu-Ming Liu, Cheng-Ta Yu, Chi-Kuang Sun, Franz Kärtner, James Fujimoto

Proceedings Volume 6118, 61180A (2006) https://doi.org/10.1117/12.644048

KEYWORDS: Femtosecond phenomena, Second-harmonic generation, Mirrors, Sapphire lasers, Crystals, Polarization, Mode locking, Reflectivity, Glasses, Signal detection

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SPIE Journal Paper | 1 September 2005 Open Access

Compact fiber-delivered Cr:forsterite laser for nonlinear light microscopy

Ming-Che Chan, Tzu-Ming Liu, Shih-Peng Tai, Chi-Kuang Sun

JBO, Vol. 10, Issue 05, 054006, (September 2005) https://doi.org/10.1117/12.10.1117/1.2060586

KEYWORDS: Fiber lasers, Dispersion, Mirrors, Microscopy, Pulsed laser operation, Femtosecond phenomena, Optical fibers, Light, Photonic crystal fibers, Output couplers

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Proceedings Article | 21 June 2004 Paper

Resonance-enhanced functional third harmonic optical microscopy

Shi-Wei Chu, Szu-Yu Chen, Tsung-Han Tsai, Tzu-Ming Liu, Shr-Bin Wu, Sajal Biring, Juen-Kai Wang, Yu-Lin Wang, Kevin Chen, Bai-Lin Lin, Chi-Kuang Sun

Proceedings Volume 5323, (2004) https://doi.org/10.1117/12.528130

KEYWORDS: Nanoparticles, Silver, Tissues, Harmonic generation, Microscopy, Resonance enhancement, Metals, Molecules, Multiphoton microscopy, Nonlinear optics

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Proceedings Article | 16 June 2004 Paper

Nano-ultrasonics: science and technology

Kung-Hsuan Lin, Chia-Lung Hsieh, Tzu-Ming Liu, Stacia Keller, Steven DenBaars, Guan-Ting Chen, Chang-Chi Pan, Jen-Inn Chyi, Chi-Kuang Sun

Proceedings Volume 5352, (2004) https://doi.org/10.1117/12.528182

KEYWORDS: Acoustics, Picosecond phenomena, Terahertz radiation, Modulation, Ultrasonics, Femtosecond phenomena, Electronic components, Control systems, Absorption, Quantum wells

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Proceedings Article | 10 July 2003 Paper

Real-time SHG imaging technique based on a 2-GHz repetition rate femtosecond Ti:sapphire laser

Shi-Wei Chu, Tzu-Ming Liu, I-Hsiu Chen, Chi-Kuang Sun, Cheng-Yung Lin, Hsui-Jen Tsai

Proceedings Volume 4963, (2003) https://doi.org/10.1117/12.478012

KEYWORDS: Second-harmonic generation, Microscopy, Sapphire lasers, Nonlinear optics, Femtosecond phenomena, Microscopes, Optical fibers, Pulsed laser operation, Light sources, Optical damage

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Proceedings Article | 4 July 2000 Paper

Multiphoton microspectroscopy of biological specimens

Bai-Ling Lin, Fu-Jen Kao, Ping Cheng, Chi-Kuang Sun, RangWu Chen, YiMin Wang, JianCheng Chen, Yung-Shun Wang, Tzu-Ming Liu, Mao-Kuo Huang

Proceedings Volume 4082, (2000) https://doi.org/10.1117/12.390530

KEYWORDS: Luminescence, Photomicroscopy, Multiphoton fluorescence microscopy, Second-harmonic generation, Optical filters, Infrared imaging, Sun, Spatial resolution, Harmonic generation, Spectrometers

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Proceedings Article | 4 July 2000 Paper

Multiphoton fluorescence spectroscopy of flourescent bioprobes and biomolecules

Ping Cheng, Bai-Ling Lin, Fu-Jen Kao, Chi-Kuang Sun, Yung-Shun Wang, Tzu-Ming Liu, YiMin Wang, JianCheng Chen, Mao-Kuo Huang, Iain Johnson

Proceedings Volume 4082, (2000) https://doi.org/10.1117/12.390527

KEYWORDS: Luminescence, Multiphoton fluorescence microscopy, Fluorescence spectroscopy, Multiphoton spectroscopy, Spectroscopy, Beam splitters, Microscopes, Multiphoton microscopy, Microscopy, Sun

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