Mr. Xiaohua Zhu Profile

Xiaohua Zhu

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Proceedings Article | 16 March 2020 Presentation + Paper

A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype

Xinbin Li, Zhiqiang Chen, Li Zhang, Hewei Gao, Chengpeng Wu, Xiaohua Zhu

Proceedings Volume 11312, 113121A (2020) https://doi.org/10.1117/12.2549560

KEYWORDS: X-rays, Imaging systems, Prototyping, X-ray imaging, Absorption, Lung, X-ray detectors, Lung imaging, Phase contrast

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By integrating three absorption gratings with a medical X-ray tube and a medical flat panel detector, a preclinical X-ray multi-contrast lung imaging prototype with a large field-of-view up to 40 × 50 cm² was developed in this work. The prototype system provides phase-contrast and dark-field images simultaneously in addition to the conventional X-ray absorption imaging. Unlike the traditional grating-based phase-contrast imaging (GPCI) system, the scanning object is placed behind the pattern-generating grating G1, reducing the radiation dose to probably half of the original system design. For a fast scan process, three absorption gratings inducing a large field-of-view were utilized. Besides, the X-ray tube, the three gratings and the detector are all fixed on the same mechanical arm, scanning the object along the vertical direction. A numerical simulation platform was developed to help optimize the imaging parameters. Finally, the preliminary experimental results of a full-body enthanized rabbit demonstrate the capability of the multi-contrast prototype system, and its dark-field images are capable of providing additional diagnostic value for the diagnosis of lung diseases. Direct evaluation of the potential clinical unity of the multi-contrast lung imaging can be further performed on this prototype system.

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