The highly sensitive Raman cell based on the hollow optical fiber that is suitable for the real-time breath analysis is
reported. Hollow optical fiber with inner coating of silver is used as a gas cell and a Stokes light collector. A very small
cell whose volume is only 0.4 ml or less enables fast response and real-time measurement of trace gases. To increase the
sensitivity the cell is arranged in a cavity which includes of a long-pass filter and a high reflective mirror. The sensitivity
of the cavity cell is more than two times higher than that of the cell without cavity.
A compact Raman cell based on the hollow optical fiber for highly sensitive breath analysis is reported. A polycarbonate
tube-based hollow optical fiber with inner coating of silver is used for both a gas cell and a Stokes collector. An
excitation laser light at 532 nm is launched into the cell filled with analytes and the Stokes light collected in the cell is
detected by the multichannel Raman spectrometer. A high-reflectivity mirror was placed at the output end of the cell for
the effective excitation of trace gases. The Raman spectrum of major breath molecule (oxygen, carbon dioxide, and
water) is obtained without a serious decrease of the signal-to-noise ratio even if the cell is coiled into a multiple loop
with a 3.8 cm radius. Because the cell examined in this report needs very small volume of only 0.4 ml or less, it has
great potential for gas analyses that need fast response such as in critical care and operating rooms.
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