Prof. Nicholas J. Durr Profile

Prof. Nicholas J. Durr

Associate Professor at Johns Hopkins Univ

SPIE Involvement:

Conference Program Committee | Editorial Board Member: Biophotonics Discovery | Editorial Board Member: Journal of Biomedical Optics | Author

Websites:

Personal Website

Publications (41)

Proceedings Article | 13 March 2024 Presentation

Widefield mapping of tissue oxygen saturation through a flexible colonoscope

Taylor Bobrow, Nicholas Durr

Proceedings Volume PC12825, PC1282504 (2024) https://doi.org/10.1117/12.3003557

KEYWORDS: Tissues, Oxygen, Reflectivity, Semiconductor lasers, Resection, Natural surfaces, Light sources and illumination, Light sources, In vivo imaging, Fiber optics

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Proceedings Article | 13 March 2024 Presentation

Computational colonoscopy

Nicholas Durr, Taylor Bobrow, Suchapa Arayakarnkul, Saowanee Ngamruengphong

Proceedings Volume PC12825, PC1282507 (2024) https://doi.org/10.1117/12.3009912

KEYWORDS: Multispectral imaging, Reflectivity, In vivo imaging, Light sources and illumination, Biological imaging, Tissues, Spatial frequencies, Multimodal imaging, Imaging systems, Image processing

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Proceedings Article | 17 March 2023 Presentation

Speckle-illumination stereo endoscopy for depth and optical property mapping

Anthony Song, Mason Chen, Nicholas Durr

Proceedings Volume PC12361, PC1236103 (2023) https://doi.org/10.1117/12.2650639

KEYWORDS: Optical properties, Endoscopy, Waveguides, Tissue optics, Speckle, Laparoscopy, Cameras, Volume rendering, Surgery, Speckle pattern

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Proceedings Article | 6 March 2023 Presentation

A retrofit colonoscope for in-vivo human multispectral, topographic, and blood flow imaging

Taylor Bobrow, Ethan Levy, John Han, Nicholas Durr

Proceedings Volume PC12371, PC123710F (2023) https://doi.org/10.1117/12.2650830

KEYWORDS: In vivo imaging, Blood circulation, Light sources, Imaging systems, Image sensors, Error control coding, Colorectal cancer, Waveguides, Visualization, Speckle imaging

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Proceedings Article | 6 March 2023 Presentation

Oblique back illumination cell phone microscopy for blood analysis

Marisa Morakis, Gregory McKay, Eli Foster, Julie Bentley, Nicholas Durr

Proceedings Volume PC12369, PC123690B (2023) https://doi.org/10.1117/12.2650918

KEYWORDS: Blood, Cell phones, Point-of-care devices, Microscopy, Phase contrast, Relays, Microscopes, Visualization, Titanium dioxide, Scattering

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Proceedings Article | 7 March 2022 Poster + Paper

Towards real-time urinalysis with holographic lens-free imaging

Gregory McKay, Anisha Oommen, Carolina Pacheco, Mason Chen, Stuart Ray, René Vidal, Benjamin Haeffele, Nicholas Durr

Proceedings Volume 11949, 119490D (2022) https://doi.org/10.1117/12.2609677

KEYWORDS: Holograms, Imaging systems, Blood, Crystals, Holography, Particles, Diagnostics, Sensors, Reconstruction algorithms, Control systems

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Proceedings Article | 4 March 2022 Presentation + Paper

A model for generating paired complete blood count and oblique back-illumination capillaroscopy data in tissue-realistic microfluidic chambers

Gregory McKay, Luojie Huang, Taylor Bobrow, Srivathsan Kalyan, Soojung Claire Hur, Sophie Lanzkron, Lydia Pecker, Alison Moliterno, Nicholas Durr

Proceedings Volume 11964, 119640G (2022) https://doi.org/10.1117/12.2609715

KEYWORDS: Blood, Microfluidics, Data modeling, Tissues, Light emitting diodes, Photoresist materials, Magnetism, In vivo imaging, Capillaries, Absorption

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Proceedings Article | 3 March 2022 Presentation + Paper

Sequential staining technique for acquiring paired images with H&E and microscopy with ultraviolet surface excitation (MUSE)

Ryan Niemeier, Gregory McKay, Mason Chen, Nakul Shankar, Alexander Baras, Elise Ng, Nicholas Durr

Proceedings Volume 11934, 1193405 (2022) https://doi.org/10.1117/12.2610334

KEYWORDS: Tissues, Imaging systems, Rhodamine, Microscopy, Tumors, Microscopes, Cameras

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Proceedings Article | 3 March 2022 Presentation + Paper

Imaging phase-function contrast with masked aperture scattering oblique plane microscopy

Ryan Niemeier, Gregory McKay, Nicholas Durr

Proceedings Volume 11974, 1197405 (2022) https://doi.org/10.1117/12.2610316

KEYWORDS: Scattering, Light scattering, Objectives, Microscopy

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Proceedings Article | 2 March 2022 Presentation + Paper

A portable, dual-channel oblique back-illumination capillaroscope for in vivo human blood cell imaging in hematology clinics

Gregory McKay, Lydia Pecker, Alison Moliterno, Sophie Lanzkron, Nicholas Durr

Proceedings Volume 11972, 1197203 (2022) https://doi.org/10.1117/12.2609706

KEYWORDS: Blood, Capillaries, Imaging systems, Tongue, In vivo imaging, Lamps, Hematology, Absorption, Microscopes, Light emitting diodes

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Proceedings Article | 2 March 2022 Presentation + Paper

A high-resolution reverse lens design for cell phone capillaroscopy blood analysis

Marisa Morakis, Gregory McKay, Nicholas Durr

Proceedings Volume 11968, 1196804 (2022) https://doi.org/10.1117/12.2610288

KEYWORDS: Cell phones, Blood, Cameras, Objectives, Modulation transfer functions, Sensors, Image resolution, Capillaries, Microscopes, Microscopy, Point-of-care devices, Mobile device imaging, Non-invasive medical diagnostics

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Proceedings Article | 5 March 2021 Presentation

Data-driven SFDI to measure molecular signals from widefield images

Nicholas Durr

Proceedings Volume 11622, 1162203 (2021) https://doi.org/10.1117/12.2590874

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Proceedings Article | 5 March 2021 Presentation

Low-cost diffuser-based computational funduscope

Yunzhe Li, Gregory McKay, Nicholas Durr, Lei Tian

Proceedings Volume 11632, 1163203 (2021) https://doi.org/10.1117/12.2578924

KEYWORDS: Eye, Reconstruction algorithms, Eye models, Point spread functions, Ophthalmoscopy, Instrument modeling, Imaging systems, Diffusers, Calibration, Wavefronts

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Proceedings Article | 5 March 2021 Presentation + Paper

Real-time oxygenation mapping from structured light imaging with deep learning

Mason Chen, Nicholas Durr

Proceedings Volume 11639, 116391D (2021) https://doi.org/10.1117/12.2578939

KEYWORDS: Structured light, Tissues, Associative arrays, Performance modeling, Model-based design, Video, Tissue optics, Spatial frequencies, Pathology, Optical networks

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Proceedings Article | 5 March 2021 Presentation + Paper

Towards SFDI endoscopy with structured illumination from randomized speckle patterns

Mason Chen, Taylor Bobrow, Nicholas Durr

Proceedings Volume 11631, 116310Y (2021) https://doi.org/10.1117/12.2578940

KEYWORDS: Endoscopy, Speckle pattern, Optical properties, Tissue optics, Speckle, Tissues, Reconstruction algorithms, Optical testing, Spatial frequencies, Silicon

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SPIE Journal Paper | 30 November 2020 Open Access

Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning

Mason T. Chen, Nicholas Durr

JBO, Vol. 25, Issue 11, 112907, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.112907

KEYWORDS: Tissues, Optical properties, In vivo imaging, Absorption, Colon, Oxygen, Performance modeling, Data modeling, Tissue optics, Chromophores

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Proceedings Article | 10 March 2020 Presentation

Generative adversarial network prediction of optical properties from wide-field images (Conference Presentation)

Nicholas Durr

Proceedings Volume 11222, 1122203 (2020) https://doi.org/10.1117/12.2550569

KEYWORDS: Optical properties, Optical networks, Tissues, Absorption, Scattering, In vivo imaging, Spatial frequencies, Statistical modeling, Statistical analysis, Error analysis

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Proceedings Article | 6 March 2020 Presentation

Generative adversarial networks in biophotonics: a tutorial with examples (Conference Presentation)

Nicholas Durr

Proceedings Volume 11211, 112110C (2020) https://doi.org/10.1117/12.2551387

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Proceedings Article | 17 February 2020 Presentation + Paper

Optimizing white blood cell contrast in graded-field capillaroscopy using capillary tissue phantoms

Gregory McKay, Taylor Bobrow, Srivathsan Kalyan, Soojung Claire Hur, Nicholas Durr

Proceedings Volume 11243, 112430Q (2020) https://doi.org/10.1117/12.2546995

KEYWORDS: Capillaries, Blood, Phase contrast, Light emitting diodes, Scattering, Tissues, Silicon, Semiconducting wafers, Absorption, Microfluidics

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Proceedings Article | 18 March 2019 Presentation + Paper

Adversarial U-net with spectral normalization for histopathology image segmentation using synthetic data

Faisal Mahmood, Richard Chen, Daniel Borders, Gregory McKay, Kevan Salimian, Alexander Baras, Nicholas Durr

Proceedings Volume 10956, 109560N (2019) https://doi.org/10.1117/12.2512918

KEYWORDS: Image segmentation, Gallium nitride, Pathology, Binary data, Associative arrays, Tissues, Medicine, Cancer, Medical imaging, Breast

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Proceedings Article | 15 March 2019 Presentation + Paper

Polyp segmentation and classification using predicted depth from monocular endoscopy

Faisal Mahmood, Ziyun Yang, Richard Chen, Daniel Borders, Wenhao Xu, Nicholas Durr

Proceedings Volume 10950, 1095011 (2019) https://doi.org/10.1117/12.2513117

KEYWORDS: Endoscopy, Colorectal cancer, Image segmentation, RGB color model, Cancer, Cameras, Biological research, Fusion energy, Biomedical engineering, Biomedical optics

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Proceedings Article | 14 March 2019 Presentation

Fusing attributes predicted via conditional GANs for improved skin lesion classification (Conference Presentation)

Faisal Mahmood, Jeremiah Johnson, Ziyun Yang, Nicholas Durr

Proceedings Volume 10950, 109501T (2019) https://doi.org/10.1117/12.2513139

KEYWORDS: Image segmentation, Skin, Gallium nitride, Skin cancer, Cancer, Melanoma, Visualization, RGB color model

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Proceedings Article | 4 March 2019 Paper

High-speed imaging of scattering particles flowing through turbid media with confocally aligned, oblique plane illumination

Gregory McKay, Alexander Trick, Nicholas Durr

Proceedings Volume 10890, 108902K (2019) https://doi.org/10.1117/12.2509865

KEYWORDS: Scattering, Capillaries, Blood, Absorption, In vivo imaging, Light scattering, Objectives, Particles, Microscopy, Imaging systems

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Proceedings Article | 4 March 2019 Presentation

Robust photometric stereo endoscopy via deep learning trained on synthetic data (Conference Presentation)

Faisal Mahmood, Daniel Borders, Richard Chen, Jordan Sweer, Steven Tilley, Norman Nishioka, J. Webster Stayman, Nicholas Durr

Proceedings Volume 10871, 108710N (2019) https://doi.org/10.1117/12.2509878

KEYWORDS: Endoscopy, Colorectal cancer, Endoscopes, Data modeling, 3D modeling, Colon, Light sources, Error analysis, Cancer, Cameras

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Proceedings Article | 4 March 2019 Paper

Speckle reduction in laser illuminated endoscopy using adversarial deep learning

Taylor Bobrow, Faisal Mahmood, Miguel Inserni, Nicholas Durr

Proceedings Volume 10889, 1088916 (2019) https://doi.org/10.1117/12.2510587

KEYWORDS: Speckle, Light emitting diodes, Endoscopy, Image processing, Light sources, Laser optics

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Proceedings Article | 27 February 2019 Paper

An adaptive-coherence light source for hyperspectral, topographic, and flow-contrast imaging

Taylor Bobrow, Nicholas Durr

Proceedings Volume 10871, 108710Y (2019) https://doi.org/10.1117/12.2510632

KEYWORDS: Speckle, Endoscopy, Light sources, Laser speckle contrast imaging, Tissue optics, Endoscopes

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Proceedings Article | 20 February 2019 Presentation + Paper

Registering large caustic distortions for high dynamic range diffuser wavefront sensing

Gregory McKay, Faisal Mahmood, Nicholas Durr

Proceedings Volume 10886, 108860Y (2019) https://doi.org/10.1117/12.2509765

KEYWORDS: Diffusers, Wavefronts, Eye, Wavefront sensors, Eye models, Image registration, Holography, Light emitting diodes, Wavefront distortions, High dynamic range imaging

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SPIE Journal Paper | 2 April 2018

Toward dynamic lumbar puncture guidance using needle-based single-element ultrasound imaging

Haichong Zhang, Younsu Kim, Melissa Lin, Mateo Paredes, Karun Kannan, Abhay Moghekar, Nicholas Durr, Emad Boctor

JMI, Vol. 5, Issue 02, 021224, (April 2018) https://doi.org/10.1117/12.10.1117/1.JMI.5.2.021224

KEYWORDS: Ultrasonography, Computer programming, Bone, Tissues, Imaging systems, Transducers, Data acquisition, Image quality, Image processing, Signal processing

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Proceedings Article | 14 March 2018 Presentation

Quantitative polyp size measurements with photometric stereo endoscopy enhanced by deep learning (Conference Presentation)

Faisal Mahmood, Norman Nishioka, Nicholas Durr

Proceedings Volume 10487, 104870G (2018) https://doi.org/10.1117/12.2290423

KEYWORDS: Endoscopy, Colorectal cancer, Endoscopes, Colon, Reconstruction algorithms, 3D displays, 3D metrology, Cancer, Cameras, Convolutional neural networks

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Proceedings Article | 14 March 2018 Presentation

Mapping optical properties of the esophagus using sub-diffuse spatial frequency domain imaging (Conference Presentation)

Jordan Sweer, Nicholas Durr

Proceedings Volume 10489, 104890L (2018) https://doi.org/10.1117/12.2290025

KEYWORDS: Tissues, Scattering, Optical properties, Esophagus, Biopsy, Optical coherence tomography, Tissue optics, Spatial frequencies, Cancer, Endoscopy

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Proceedings Article | 2 March 2018 Paper

Deep learning-based depth estimation from a synthetic endoscopy image training set

Faisal Mahmood, Nicholas Durr

Proceedings Volume 10574, 1057421 (2018) https://doi.org/10.1117/12.2293785

KEYWORDS: Endoscopy, Colon, Colorectal cancer, Endoscopes, Cancer, 3D modeling, Cameras, Image analysis

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Proceedings Article | 3 March 2017 Presentation + Paper

Toward dynamic lumbar punctures guidance based on single element synthetic tracked aperture ultrasound imaging

Haichong Zhang, Melissa Lin, Younsu Kim, Mateo Paredes, Karun Kannan, Nisu Patel, Abhay Moghekar, Nicholas Durr, Emad Boctor

Proceedings Volume 10135, 101350J (2017) https://doi.org/10.1117/12.2256040

KEYWORDS: Ultrasonography, Transducers, Bone, Imaging systems, Synthetic aperture radar, Emergency medicine, Diagnostics and therapeutics, Computer programming, Spine, Image resolution, Detection and tracking algorithms, Metals

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SPIE Journal Paper | 17 September 2015 Open Access

Tripling the maximum imaging depth with third-harmonic generation microscopy

Murat Yildirim, Nicholas Durr, Adela Ben-Yakar

JBO, Vol. 20, Issue 09, 096013, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.096013

KEYWORDS: Tissues, Microscopy, Laser tissue interaction, Natural surfaces, Absorption, Scattering, Third-harmonic generation, Monte Carlo methods, Tissue optics, Temperature metrology

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Proceedings Article | 28 February 2014 Paper

Improving multiphoton microscopy using annular beam shaping, focusing on imaging of human skin

Johan Borglin, Nicholas Durr, Stina Guldbrand, Onur Ferhanoglu, Ann-Marie Wennberg, Dag Hanstorp, Adela Ben-Yakar, Marica Ericson

Proceedings Volume 8948, 89482K (2014) https://doi.org/10.1117/12.2038942

KEYWORDS: Optical simulations, Beam shaping, Skin, Multiphoton microscopy, Point spread functions, Light scattering, Luminescence, Microscopes, Signal attenuation, Monte Carlo methods

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Proceedings Article | 27 February 2014 Paper

System for clinical photometric stereo endoscopy

Nicholas Durr, Germán González, Daryl Lim, Giovanni Traverso, Norman Nishioka, Benjamin Vakoc, Vicente Parot

Proceedings Volume 8935, 89351F (2014) https://doi.org/10.1117/12.2038119

KEYWORDS: Endoscopy, Video, Endoscopes, Light sources, Video processing, Image processing, Colon, Light emitting diodes, Tissues, Optical fibers

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SPIE Journal Paper | 17 July 2013 Open Access

Photometric stereo endoscopy

Vicente Parot, Daryl Lim, German Gonzalez, Giovanni Traverso, Norman Nishioka, Benjamin Vakoc, Nicholas Durr

JBO, Vol. 18, Issue 07, 076017, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.076017

KEYWORDS: Endoscopy, Light sources, Endoscopes, Tissues, Prototyping, Natural surfaces, Cameras, Colon, Picosecond phenomena, Imaging systems

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SPIE Journal Paper | 1 August 2011 Open Access

First-in-human pilot study of a spatial frequency domain oxygenation imaging system

Sylvain Gioux, Alan Stockdale, Rafiou Oketokoun, Yoshitomo Ashitate, Nicholas Durr, Lorissa Moffitt, John Frangioni, Amaan Mazhar, Bruce Tromberg, Anthony Durkin, Bernard Lee, Samuel Lin, Adam Tobias, David Cuccia, Edward Kelly, Maxwell Weinmann

JBO, Vol. 16, Issue 08, 086015, (August 2011) https://doi.org/10.1117/12.10.1117/1.3614566

KEYWORDS: Imaging systems, Tissues, Surgery, Skin, Light sources, Near infrared, Digital micromirror devices, Oxygen, Chromophores, Optical properties

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Proceedings Article | 17 February 2011 Open Access

Preclinical and clinical validation of a novel oxygenation imaging system

Sylvain Gioux, Amaan Mazhar, Bernard Lee, David Cuccia, Alan Stockdale, Rafiou Oketokoun, Yoshitomo Ashitate, Nicholas Durr, Anthony Durkin, Bruce Tromberg, John Frangioni

Proceedings Volume 7896, 78961R (2011) https://doi.org/10.1117/12.875603

KEYWORDS: Imaging systems, Surgery, Near infrared, Cameras, Optical properties, Light sources, Skin, Tissues, Oxygen, Diodes

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SPIE Journal Paper | 1 February 2011 Open Access

Maximum imaging depth of two-photon autofluorescence microscopy in epithelial tissues

Nicholas Durr, Adela Ben-Yakar, Christian Weisspfennig, Benjamin Holfeld

JBO, Vol. 16, Issue 02, 026008, (February 2011) https://doi.org/10.1117/12.10.1117/1.3548646

KEYWORDS: Luminescence, Tissues, Scattering, Monte Carlo methods, Biopsy, Microscopy, Photons, Two photon imaging, Objectives, Natural surfaces

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Proceedings Article | 28 September 2007 Paper

Gold nanorods for optimized two-photon luminescence imaging of cancerous tissue

Nicholas Durr, Benjamin Holfeld, Timothy Larson, Danielle Smith, Brian Korgel, Konstantin Sokolova, Adela Ben-Yakar

Proceedings Volume 6641, 66410O (2007) https://doi.org/10.1117/12.735296

KEYWORDS: Gold, Cancer, Tissues, Luminescence, Objectives, Two photon imaging, Collagen, Point spread functions, Imaging systems, Nanorods

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Proceedings Article | 12 July 2007 Paper

Two-photon luminescence imaging of cancerous tissue using gold nanorods as bright contrast agents

Nicholas Durr, Benjamin Holfeld, Timothy Larson, Danielle Smith, Brian Korgel, Konstantin Sokolova, Adela Ben-Yakar

Proceedings Volume 6630, 66300Q (2007) https://doi.org/10.1117/12.728601

KEYWORDS: Gold, Cancer, Tissues, Luminescence, Objectives, Two photon imaging, Collagen, Point spread functions, Imaging systems, Nanorods

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Showing 5 of 41 publications

Conference Committee Involvement (2)

Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences II

25 January 2025 | San Francisco, California, United States

Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences

27 January 2024 | San Francisco, California, United States

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