Photothermal therapy is a tumor target therapy, which can induce temperature increase by laser in tumor tissue to eliminate cancer cells, without affecting surrounding healthy tissue. The temperature distribution in the tumor tissue directly determine the therapeutic efficacy. Therefore, real-time temperature monitoring is particularly important during photothermal therapy. However, accurate real-time temperature measurements in deep tissue still face many obstacles. This paper shows the feasibility of photoacoustic technology for real-time temperature monitoring with or without nanomaterials as photoacoustic contrast agents.
In this paper, we proposed a photoacoustic (PA) method for detecting liquid viscosity based on frequency-resolved measurement. A negative correlation was investigated theoretically between the liquid viscosity and the full width at half maximum (FWHM) of the PA frequency spectrum. To test the feasibility of this method, water mixed with different concentrations of ink and glycerol was measured. The results indicate that liquids with higher viscosity will lead to a higher FWHM reduction in the PA frequency spectrum and the frequency spectrum was independent from the absorption coefficient of the liquid, which demonstrate that this technique has future potential clinical applications for monitoring the viscosity changes in subcutaneous microvasculature.
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