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16 March 2023 Broadband label-free vibrational imaging in the fingerprint region at <1-ms pixel dwell time via deep learning (Conference Presentation)
Federico Vernuccio, Arianna Bresci, Alejandro De la Cadena, Chiara Ceconello, Francesco Manetti, Salvatore Sorrentino, Renzo Vanna, Giulio Cerullo, Dario Polli
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Proceedings Volume PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII; PC123900L (2023) https://doi.org/10.1117/12.2648418
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We propose a novel approach to broadband coherent anti-Stokes Raman scattering (B-CARS) based on a femtosecond laser at 1035 nm and 2 MHz repetition rate. These features of the driving laser enable white-light continuum generation in bulk media, employed as broadband Stokes. In this way, we demonstrate state-of-the-art acquisition speed (<1 ms/pixel) with unprecedented sensitivity (≈14.1 mmol/L) when detecting dimethyl-sulfoxide in water, covering the whole fingerprint region. To further enhance the performance of the system, we designed an innovative spectral denoiser based on a convolutional neural network, coupled with a post-processing pipeline to distinguish different chemical species of biological tissues.
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Federico Vernuccio, Arianna Bresci, Alejandro De la Cadena, Chiara Ceconello, Francesco Manetti, Salvatore Sorrentino, Renzo Vanna, Giulio Cerullo, and Dario Polli "Broadband label-free vibrational imaging in the fingerprint region at <1-ms pixel dwell time via deep learning (Conference Presentation)", Proc. SPIE PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII, PC123900L (16 March 2023); https://doi.org/10.1117/12.2648418
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KEYWORDS
Femtosecond phenomena
Microscopes
Microscopy
Picosecond phenomena
Raman spectroscopy
Signal generators
Spectroscopy
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