Changes in lipid metabolism in hypoxic cancer cells revealed by hyperspectral stimulated Raman scattering microscopy (Conference Presentation)

Gil Gonzalez; Matthew Clark; Ezinne Osuji; Chi Zhang

doi:10.1117/12.2655611

15 March 2023 Changes in lipid metabolism in hypoxic cancer cells revealed by hyperspectral stimulated Raman scattering microscopy (Conference Presentation)

Gil Gonzalez, Matthew Clark, Ezinne Osuji, Chi Zhang

Author Affiliations +

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC1239210 (2023) https://doi.org/10.1117/12.2655611
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cancer cells in the hypoxic environment alter their metabolism to address the low oxygen stress. Such metabolic changes contribute to cancer resistance to chemotherapy and radiotherapy treatment. Understanding the hypoxia-induced metabolic changes allows for finding new targets to treat hypoxic cancer cells. We applied stimulated Raman scattering spectroscopic imaging to explore the metabolic changes of cancer cells exposed to hypoxia. We found spatial redistribution and content changes of lipid droplets (LDs) in various cancer types. We also studied the sources contributing to the formation of LDs and discovered the relationship between LD formation and endoplasmic reticulum stress.

Conference Presentation

Citation Download Citation

Gil Gonzalez, Matthew Clark, Ezinne Osuji, and Chi Zhang "Changes in lipid metabolism in hypoxic cancer cells revealed by hyperspectral stimulated Raman scattering microscopy (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC1239210 (15 March 2023); https://doi.org/10.1117/12.2655611

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