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5 October 2023 Cancer cell mechanics: from the optical stretcher to clinical applications
Josef A. Käs
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Proceedings Volume PC12649, Optical Trapping and Optical Micromanipulation XX; PC1264904 (2023) https://doi.org/10.1117/12.2680873
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States
Abstract
Cancer cells tend to soften, which may enhance their ability to squeeze through dense tissue. This cell softening has been demonstrated with the optical stretcher technology. Based on these fundamental findings we have developed a histophatological prognostic marker for distant metastasis. In a retrospective clinical study with 1380 breast cancer patients we have validated this approach. The new marker should apply to 92% of all cancers and will avoid over- and undertreatment of patients..
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Josef A. Käs "Cancer cell mechanics: from the optical stretcher to clinical applications", Proc. SPIE PC12649, Optical Trapping and Optical Micromanipulation XX, PC1264904 (5 October 2023); https://doi.org/10.1117/12.2680873
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KEYWORDS
Cancer
Biomedical applications
Cell mechanics
Tumors
Breast cancer
Fluid dynamics
Physical phenomena
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