Using optical coherence tomography to detect bacterial biofilms on foley catheters (Conference Presentation)

Andrew E. Heidari; Kyungjin Oh; Zhongping Chen

doi:10.1117/12.2251242

19 April 2017 Using optical coherence tomography to detect bacterial biofilms on foley catheters (Conference Presentation)

Andrew E. Heidari, Kyungjin Oh, Zhongping Chen

Author Affiliations +

Proceedings Volume 10038, Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices; 1003806 (2017) https://doi.org/10.1117/12.2251242
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Urinary tract infections(UTI) pose a serious problem for hospital patients accounting for 33% of all hospital acquired(nosocomial) infections with indwelling foley catheters. The presence of an indwelling foley catheter provides a scaffolding for circulating planktonic bacteria to adhere to and to form microbial biofilm communities that would typically be hindered by the body’s innate immune system response. It is these biofilm communities that form on the inner lumen of foley catheters that provide a reservoir of pathogenic bacteria that could dislodge or disperse from the biofilm and infect urethra or bladder mucosal tissue in the urinary tract. Current diagnostic techniques of urine microbiological cultures are lacking in differentiating asymptomatic bacteriuria and symptomatic catheter-associated urinary tract infection(CAUTI) since almost all patients with chronic indwelling catheters are almost universally bacteriuruic. There is an unmet need of a diagnostic tool to assess the difference between the pathogenesis of asymptomatic bacteriuria and CAUTI, specifically at the site of the native biofilm formation. Optical Coherence Tomography(OCT) is an emerging high resolution, minimally invasive tomographic imaging technique that has shown promise in imaging biofilm structures previously in an endoscopic setting of the airway in-vivo and in microfluidic chambers. OCT can be adapted to image various sized biological surfaces and orifices such as airway branches and blood vessels by using a variety of minature endoscopic probes. In this work OCT will be used to image biofilm structure in-vitro on the inner lumen of extravasated critical care patient’s foley catheters. Scanning electron microscopy will be conducted post OCT to confirm the presence of bacterial biofilm in OCT images.

Conference Presentation

Citation Download Citation

Andrew E. Heidari, Kyungjin Oh, and Zhongping Chen "Using optical coherence tomography to detect bacterial biofilms on foley catheters (Conference Presentation)", Proc. SPIE 10038, Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices, 1003806 (19 April 2017); https://doi.org/10.1117/12.2251242

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KEYWORDS

Optical coherence tomography

Diagnostics

Endoscopy

Pathogens

Bacteria

Bladder

Coherence (optics)

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