Coagulation monitoring based on blood elastic measurement using optical coherence tomography

Xiangqun Xu; Jiang Zhu; Zhongping Chen

doi:10.1117/12.2248450

17 February 2017 Coagulation monitoring based on blood elastic measurement using optical coherence tomography

Xiangqun Xu, Jiang Zhu, Zhongping Chen

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 1005332 (2017) https://doi.org/10.1117/12.2248450
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Blood coagulation monitoring is important to diagnose hematological diseases and cardiovascular diseases and to predict the risk of bleeding and excessive clotting. In this study, we developed a system to dynamically monitor blood coagulation and quantitatively determine the coagulation function by blood elastic measurement. When blood forms a clot from a liquid, ultrasonic force induces a shear wave, which is detected by optical coherence tomography (OCT). The coagulation of porcine whole blood recalcified by calcium chloride is assessed using the metrics of reaction time, clot formation kinetics and maximum shear modulus. The OCE system can noninvasively monitor the blood coagulation and quantitatively determine the coagulation function.

Citation Download Citation

Xiangqun Xu, Jiang Zhu, and Zhongping Chen "Coagulation monitoring based on blood elastic measurement using optical coherence tomography", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005332 (17 February 2017); https://doi.org/10.1117/12.2248450

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