Considerations for ex vivo thermal tissue testing exemplified using the fresh porcine longissimus muscle model for endometrial ablation

James H. Fugett II; Haydon E. Bennett; Joshua L. Shrout; James E. Coad

doi:10.1117/12.2252308

22 February 2017 Considerations for ex vivo thermal tissue testing exemplified using the fresh porcine longissimus muscle model for endometrial ablation

James H. Fugett II, Haydon E. Bennett, Joshua L. Shrout, James E. Coad

Author Affiliations +

Proceedings Volume 10066, Energy-based Treatment of Tissue and Assessment IX; 100660L (2017) https://doi.org/10.1117/12.2252308
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Expansions in minimally invasive medical devices and technologies with thermal mechanisms of action are continuing to advance the practice of medicine. These expansions have led to an increasing need for appropriate animal models to validate and quantify device performance. The planning of these studies should take into consideration a variety of parameters, including the appropriate animal model (test system - ex vivo or in vivo; species; tissue type), treatment conditions (test conditions), predicate device selection (as appropriate, control article), study timing (Day 0 acute to more than Day 90 chronic survival studies), and methods of tissue analysis (tissue dissection - staining methods). These considerations are discussed and illustrated using the fresh extirpated porcine longissimus muscle model for endometrial ablation.

Citation Download Citation

James H. Fugett II, Haydon E. Bennett, Joshua L. Shrout, and James E. Coad "Considerations for ex vivo thermal tissue testing exemplified using the fresh porcine longissimus muscle model for endometrial ablation", Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 100660L (22 February 2017); https://doi.org/10.1117/12.2252308

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