Excimer Laser Angioplasty: Initial Clinical Results With A Percutaneous Transluminal Procedure In Total Peripheral Artery Occlusion

Gregor Wollenek; Gunther Laufer; Kristian Hohla; Florian Grabenwoger; Walter Klepetko

doi:10.1117/12.950160

26 April 1989 Excimer Laser Angioplasty: Initial Clinical Results With A Percutaneous Transluminal Procedure In Total Peripheral Artery Occlusion

Gregor Wollenek, Gunther Laufer, Kristian Hohla, Florian Grabenwoger, Walter Klepetko

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Proceedings Volume 1023, Excimer Lasers and Applications; (1989) https://doi.org/10.1117/12.950160
Event: 1988 International Congress on Optical Science and Engineering, 1988, Hamburg, Germany

Abstract

Laser energy has the potential to recanalize obstructive atherosclerotic vessels as an alternative or an adjunct to either bypass surgery or balloon angioplasty. But conventional lasers cause thermal side effects which may lead to extensive damage to neighboring layers. In contrast, excimer laser irradiation in the far ultraviolet range has proved to minimize or avoid these injuries to vessel walls. To evaluate the clinical feasibility of excimer laser angioplasty (ELA), we have performed basic investigations including histologic examination by light microscopy, scanning and electron microscopy, and temperature measurements, and later on in vivo animal trials. Using 308 nm irradiation (XeCl) we have treated the first patient ever to undergo ELA, and the procedure was successful: after recanalization of a total occlusion of a superficial femoral artery, dilatation resulted in sufficient blood supply to the periphery.

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Gregor Wollenek, Gunther Laufer, Kristian Hohla, Florian Grabenwoger, and Walter Klepetko "Excimer Laser Angioplasty: Initial Clinical Results With A Percutaneous Transluminal Procedure In Total Peripheral Artery Occlusion", Proc. SPIE 1023, Excimer Lasers and Applications, (26 April 1989); https://doi.org/10.1117/12.950160

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KEYWORDS

Excimer lasers

Laser therapeutics

Laser tissue interaction

Arteries

Laser ablation

Scanning electron microscopy

Ultraviolet radiation

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