Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer

Barry Cense; Maddipatla Reddikumar; Joel Cervantes

doi:10.1117/12.2275020

18 April 2017 Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer

Barry Cense, Maddipatla Reddikumar, Joel Cervantes

Author Affiliations +

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102510S (2017) https://doi.org/10.1117/12.2275020
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

A spectrometer design with a multiple line line-scan camera and beam displacer is presented for ultra-high resolution optical coherence tomography measurements of the human retina at 840 nm. The beam displacer offsets the two orthogonal polarization states on the same line-scan camera, which reduces k-space mapping complexity, as data in both polarization channels can be mapped with the same procedure. Its coherence length is 2.8 μm in tissue (n = 1.38). Birefringence values of 1°/μm and higher were found in a circle with a radius of 2.5° eccentricity centered on the fovea, and in the raphe, pointing at a higher packing density of microtubules and a lower concentration of glia. Birefringence measurements may be more helpful in the modeling of individual structure-function maps than thickness measurements, as they are not affected by glial content.

Citation Download Citation

Barry Cense, Maddipatla Reddikumar, and Joel Cervantes "Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102510S (18 April 2017); https://doi.org/10.1117/12.2275020

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