Finite element model for the simulation of laser activated micro- and nano-scale drug delivery systems

Henrique Vilhena; João M. P. Coelho; José M. Rebordão

doi:10.1117/12.2272721

22 August 2017 Finite element model for the simulation of laser activated micro- and nano-scale drug delivery systems

Henrique Vilhena, João M. P. Coelho, José M. Rebordão

Proceedings Volume 10453, Third International Conference on Applications of Optics and Photonics; 104531Y (2017) https://doi.org/10.1117/12.2272721
Event: Third International Conference on Applications of Optics and Photonics, 2017, Faro, Portugal

Abstract

This paper describes a flexible model that can be used to simulate laser-based photoactivation of drug delivery systems. It considers Gaussian beams for the excitation while the heat diffusion equation is solved by use of the finite element method. As an example, a typical liposome geometry in the focal volume of a laser beam is simulated and the results are compared with experimental data obtained in the literature, showing a good agreement. The model has potential in the design of drug delivery systems as it can be a starting point for the development of new kinds of micro- and nano-scale drug delivery systems.

Citation Download Citation

Henrique Vilhena, João M. P. Coelho, and José M. Rebordão "Finite element model for the simulation of laser activated micro- and nano-scale drug delivery systems", Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 104531Y (22 August 2017); https://doi.org/10.1117/12.2272721

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