Saturation measurement accuracy in clinical near-infrared cerebral oximeters with a 3D-printed channel array phantom

Ali Afshari; Pejhman Ghassemi; Molly Halprin; Jonathan Lin; Sandy Weininger; Amir H. Gandjbakhche; Jianting Wang; Joshua Pfefer

doi:10.1117/12.2290771

19 February 2018 Saturation measurement accuracy in clinical near-infrared cerebral oximeters with a 3D-printed channel array phantom

Ali Afshari, Pejhman Ghassemi, Molly Halprin, Jonathan Lin, Sandy Weininger, Amir H. Gandjbakhche, Jianting Wang, Joshua Pfefer

Author Affiliations +

Proceedings Volume 10486, Design and Quality for Biomedical Technologies XI; 104860R (2018) https://doi.org/10.1117/12.2290771
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Clinical cerebral oximeters based on near-infrared spectroscopy (NIRS) are a commonly used, non-invasive tool for intraoperative monitoring of hemoglobin saturation. Research to verify performance of cerebral oximeters in human subject trials has shown differences between commercially available devices. Test methods based on tissue-simulating phantoms have been proposed to augment clinical findings. While prior studies have focused on liquid phantoms, this work is aimed at developing methods based on solid polymer phantoms that are stable. Specifically, we have designed and fabricated a neonatal/pediatric head mimicking layered phantoms based on a 3D-printed cerebral matrix incorporating an array of vessel-simulating linear channels. Superficial layers incorporating homogeneous molded polydimethylsiloxane (PDMS) slabs were fabricated to represent CSF, scalp and skull regions. The cerebral matrix was filled with bovine blood desaturated with sodium dithionite to achieve oxygenation levels across the 40-90% range. Measurements were performed with a commercially available cerebral oximeter using two probes with different illumination-collection geometries, as designed for neonatal and pediatric patients. Reference measurements of samples were performed with a CO-oximeter before injection and after extraction. Results from applied cerebral oximeters indicate a strong sensitivity to the thickness of the superficial layer of the phantom. Better correlation with the reference CO-oximeter results were obtained in the superficial layer thickness of 0.8-2.5 mm range. Channel array phantoms with modular superficial layers represent a promising approach for performance testing of NIRS-based cerebral oximeters.

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Ali Afshari, Pejhman Ghassemi, Molly Halprin, Jonathan Lin, Sandy Weininger, Amir H. Gandjbakhche, Jianting Wang, and Joshua Pfefer "Saturation measurement accuracy in clinical near-infrared cerebral oximeters with a 3D-printed channel array phantom", Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI, 104860R (19 February 2018); https://doi.org/10.1117/12.2290771

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