Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging

Yung-Ching Chang; Li-Ching Huang; Wei-Lun Sun; Shih Yi Chuang; Tien-Hsin Lin; Yi-Syuan Wu; Chun-I Sze; Shiuan-Yeh Chen

doi:10.1117/12.2290194

13 February 2018 Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging

Yung-Ching Chang, Li-Ching Huang, Wei-Lun Sun, Shih Yi Chuang, Tien-Hsin Lin, Yi-Syuan Wu, Chun-I Sze, Shiuan-Yeh Chen

Proceedings Volume 10490, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry; 1049006 (2018) https://doi.org/10.1117/12.2290194
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

GBM (Glioblastoma Multiforme), a fatal brain tumor, is highly infiltrative and difficult to be completely removed by the surgery. In this work, the Raman tags based on the plasmonic core-satellite assemblies with ~1 nm internal gap accompanied by extremely high gap field have been fabricated and applied to GBM cell labeling. The brightness of the Raman tags is comparable to the fluorophores. The GBM cells with overexpression of EGFR are labeled with these Raman tags and can be distinguished from the normal cells through Raman imaging.

Citation Download Citation

Yung-Ching Chang, Li-Ching Huang, Wei-Lun Sun, Shih Yi Chuang, Tien-Hsin Lin, Yi-Syuan Wu, Chun-I Sze, and Shiuan-Yeh Chen "Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging", Proc. SPIE 10490, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry, 1049006 (13 February 2018); https://doi.org/10.1117/12.2290194

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