In vivo imaging prednisolone-induced osteoporosis of the adult zebrafish with spectral domain optical coherence tomography

Yanping Lin; Xiang Xiang; Tingru Chen; Chudan Gao; Hongbo Fu; Limei Wang; Jian Zhang

doi:10.1117/12.2502424

23 October 2018 In vivo imaging prednisolone-induced osteoporosis of the adult zebrafish with spectral domain optical coherence tomography

Yanping Lin, Xiang Xiang, Tingru Chen, Chudan Gao, Hongbo Fu, Limei Wang, Jian Zhang

Author Affiliations +

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 1082037 (2018) https://doi.org/10.1117/12.2502424
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Osteoporosis studies require precise visualization of the morphological structures. The adult zebrafish represents an excellent model to investigate osteoporosis. However, few imaging methods can effectively detect the adult zebrafish bone structure in real time with high resolution and good penetration depth. In this paper, long-term in vivo monitoring of Prednisolone-induced osteoporosis is achieved with spectral-domain optical coherence tomography (SD-OCT). The SD-OCT is able to noninvasively visualize the skull injury and osteoporosis of adult zebrafish. Valuable phenomenon such as the skull defect and bone loss can be conducted based on the SD-OCT images at different time points during a period of 21 days.

Citation Download Citation

Yanping Lin, Xiang Xiang, Tingru Chen, Chudan Gao, Hongbo Fu, Limei Wang, and Jian Zhang "In vivo imaging prednisolone-induced osteoporosis of the adult zebrafish with spectral domain optical coherence tomography", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 1082037 (23 October 2018); https://doi.org/10.1117/12.2502424

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