Nano sensitive study and fractal analysis of segmented retinal layers in Fourier domain OCT: promises for early disease detection

Nandan Das; Sean O'Gorman; Sergey Alexandrov; Rajib Dey; Jay Chhablani; Nirmalya Ghosh; Martin Leahy

doi:10.1117/12.2510410

28 February 2019 Nano sensitive study and fractal analysis of segmented retinal layers in Fourier domain OCT: promises for early disease detection

Nandan Das, Sean O'Gorman, Sergey Alexandrov, Rajib Dey, Jay Chhablani, Nirmalya Ghosh, Martin Leahy

Author Affiliations +

Proceedings Volume 10858, Ophthalmic Technologies XXIX; 1085821 (2019) https://doi.org/10.1117/12.2510410
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Initial study found that depth-resolved refractive index variations encoded in retinal optical coherence tomography (OCT) exhibits multifractality. Interestingly, automated segmented different layers of the retina exhibited different degree of multifractality in a human eye. In an advanced study, we have adopted nano sensitive study of spectral contents of OCT signals before retinal image construction of a human eye. We have identified and constructed most contributed submicron structural spatial period OCT images. We have quantified nano structural morphological alteration in human retinal layers as deformation progress. This innovative approach promises to develop nano sensitive diagnostic tool for early disease detection in the human eye.

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Nandan Das, Sean O'Gorman, Sergey Alexandrov, Rajib Dey, Jay Chhablani, Nirmalya Ghosh, and Martin Leahy "Nano sensitive study and fractal analysis of segmented retinal layers in Fourier domain OCT: promises for early disease detection", Proc. SPIE 10858, Ophthalmic Technologies XXIX, 1085821 (28 February 2019); https://doi.org/10.1117/12.2510410

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