Tolerating uncertainty: photodynamic therapy planning with optical property variation

Abdul-Amir Yassine; Lothar Lilge; Vaughn Betz

doi:10.1117/12.2508580

28 February 2019 Tolerating uncertainty: photodynamic therapy planning with optical property variation

Abdul-Amir Yassine, Lothar Lilge, Vaughn Betz

Proceedings Volume 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII; 108600B (2019) https://doi.org/10.1117/12.2508580
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Treatment planning is of utmost importance in interstitial photodynamic therapy, as it predicts the required light delivery to the target volume in an upcoming treatment. However, planning remains a major challenge due to several uncertainties such as the tissue optical properties and the concentrations of the photosensitizer and oxygen. Any difference in these parameters from the assumed values during planning could significantly affect the outcome of the actual treatment. This work introduces PDT-SPACE, a PDT light source power allocation using a convex optimization engine to minimize damage to organs-at-risk (OAR) with robustness against variation in tissue optical properties. Three power allocation methods are proposed and compared with respect to the resulting standard deviation in the damage to organs-at-risk and their runtime. The proposed approaches are demonstrated for ALA induced PpIX as photosensitizer in a virtual brain tumor that models a glioblastoma multiforme case. Results show that choosing a power allocation to minimize the OAR damage standard deviation under optical property variation tends to also minimize the tumor coverage as there is only one degree of freedom to optimize upon. This motivates simultaneous source position and power allocation optimization.

Conference Presentation

Citation Download Citation

Abdul-Amir Yassine, Lothar Lilge, and Vaughn Betz "Tolerating uncertainty: photodynamic therapy planning with optical property variation ", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600B (28 February 2019); https://doi.org/10.1117/12.2508580

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available