Fusion of optical coherence tomography and mesoscopic fluorescence molecular tomography via Laplacian spatial priors (Conference Presentation)

Denzel E. Faulkner; Ruoyang Yao; David M. Kingsley; David T. Corr; Xavier Intes

doi:10.1117/12.2508819

4 March 2019 Fusion of optical coherence tomography and mesoscopic fluorescence molecular tomography via Laplacian spatial priors (Conference Presentation)

Denzel E. Faulkner, Ruoyang Yao, David M. Kingsley, David T. Corr, Xavier Intes

Author Affiliations +

Proceedings Volume 10871, Multimodal Biomedical Imaging XIV; 108710C (2019) https://doi.org/10.1117/12.2508819
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Over the past three decades, non-invasive molecular imaging via optical tomography has garnered attention in the field of preclinical imaging thanks to its high sensitivity and ability to image multiple biomarkers simultaneously. However, it is still very challenging to image intact tissues with high resolution while retaining the two aforementioned characteristics. Over the last few years, our group has pioneered Mesoscopic Fluorescence Molecular Tomography (MFMT), a novel imaging modality that recapitulates the 3D distribution of fluorescent markers within thick and diffuse samples (< 3 mm) with spatial resolution ~100 µm. Still, as a diffuse optical inverse problem, the image formation can be challenging due to its ill-conditioned nature. Herein, we report on the fusion of MFMT with Optical Coherence Tomography (OCT) to provide both structural and molecular imaging capabilities. Moreover, we leverage the OCT information to impart structural priors that facilitate the optical inverse problem in MFMT. We demonstrate the capability and utility of this novel platform on bioprinted tissues, fluorescent polymer letters in agar phantoms, and on microfabricated beads at different imaging depths.

Conference Presentation

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Denzel E. Faulkner, Ruoyang Yao, David M. Kingsley, David T. Corr, and Xavier Intes "Fusion of optical coherence tomography and mesoscopic fluorescence molecular tomography via Laplacian spatial priors (Conference Presentation)", Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710C (4 March 2019); https://doi.org/10.1117/12.2508819

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KEYWORDS

Optical coherence tomography

Fluorescence tomography

Luminescence

Tomography

Inverse optics

Inverse problems

Molecular imaging

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