Dynamic measurements of absolute cerebral blood flow with coherent hemodynamics spectroscopy

Thao Pham; Angelo Sassaroli; Giles Blaney; Sergio Fantini

doi:10.1117/12.2509772

1 March 2019 Dynamic measurements of absolute cerebral blood flow with coherent hemodynamics spectroscopy

Thao Pham, Angelo Sassaroli, Giles Blaney, Sergio Fantini

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741D (2019) https://doi.org/10.1117/12.2509772
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We used coherent hemodynamics spectroscopy (CHS) and near-infrared spectroscopy (NIRS) for dynamic measurements of absolute cerebral blood flow (CBF) in one healthy subject over the prefrontal cortex. Temporal transients in mean arterial pressure (MAP) and CBF were induced by rapid deflation of pneumatic thigh cuffs following a sustained 2-minute occlusion at a super-systolic pressure. We studied the sensitivity of relative and absolute measurements of CBF with NIRS-CHS (CBF_NIRS-CHS) to the physiological parameters in the CHS model. The temporal dynamics of CBF_NIRS-CHS were compared with co-localized NIRS measurements of hemoglobin difference ([HbD] = [HbO₂]−[Hb]), and with diffuse correlation spectroscopy (DCS) measurements of relative CBF. We demonstrated that NIRS-CHS provides quantitative measurements of absolute baseline CBF, and corrects [HbD] estimations of CBF dynamics for blood volume contributions and for blood transit times in the microvasculature resulting in a better agreement with CBF dynamics measured by DCS.

Conference Presentation

Citation Download Citation

Thao Pham, Angelo Sassaroli, Giles Blaney, and Sergio Fantini "Dynamic measurements of absolute cerebral blood flow with coherent hemodynamics spectroscopy", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741D (1 March 2019); https://doi.org/10.1117/12.2509772

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