A commercialized Microelectromechanical Systems (MEMS)-based rapid scanning photoacoustic microscopy system with switchable optical and acoustic resolutions

Yang Pu; Renzhe Bi; Joongho Ahn; Jinyoung Kim; Chulhong Kim; Malini Olivo; Xiaojie Zhao

doi:10.1117/12.2506179

27 February 2019 A commercialized Microelectromechanical Systems (MEMS)-based rapid scanning photoacoustic microscopy system with switchable optical and acoustic resolutions

Yang Pu, Renzhe Bi, Joongho Ahn, Jinyoung Kim, Chulhong Kim, Malini Olivo, Xiaojie Zhao

Author Affiliations +

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 1087843 (2019) https://doi.org/10.1117/12.2506179
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

A Microelectromechanical Systems (MEMS)-based rapid scanning photoacoustic microscopy (PAM) is available to help life science research in neuroscience, cell biology, and in vivo imaging. MicroPhotoAcoustics (MPA; Ronkonkoma, NY), the only manufacturer and vendor of Optical Resolution (OR)-PAM systems, has developed a commercial PAM system with switchable optical and acoustic resolution (OR- and AR-PAM). To achieve real-time imaging capability without sacrificing high signal-to-noise ratios (SNRs), a 2-axis water-proofing MEMS scanner made of flexible polydimethylsiloxane (PDMS) was demonstrated by collaboration with Pohang University of Science and Technology (South Korea) that promises to dramatically increase the system’s imaging speed. This flexible scanner results in a wide scanning range and a fast imaging speed (5 B-scan images per second). Equipped with different excitation sources, in vivo PA images of microvasculatures in a mouse ear was obtained. The lateral and axial resolutions of the OR-PAM system are 4.38 μm. It is expected that this MEMS-based fast OR-PAM system can be significantly useful in both preclinical and clinical applications. With the continuation of new technological advancements and discoveries, MPA plans to further advance PAM to achieve faster imaging speed, higher spatial resolution at deeper tissue layer, and address a broader range of biomedical applications.

Citation Download Citation

Yang Pu, Renzhe Bi, Joongho Ahn, Jinyoung Kim, Chulhong Kim, Malini Olivo, and Xiaojie Zhao "A commercialized Microelectromechanical Systems (MEMS)-based rapid scanning photoacoustic microscopy system with switchable optical and acoustic resolutions", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 1087843 (27 February 2019); https://doi.org/10.1117/12.2506179

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Imaging systems

Microelectromechanical systems

Acoustics

Photoacoustic microscopy

Tissue optics

Nd:YAG lasers

Optical resolution

Show All Keywords

Keywords/Phrases

Search In:

Publication Years