Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips

Zdeněk Pilát; Martin Kizovský; Jan Ježek; Stanislav Krátký; Jaroslav Sobota; Martin Šiler; Ota Samek; Tomáš Buryška; Pavel Vaňáček; Jiří Damborský; Zbyněk Prokop; Pavel Zemánek

doi:10.1117/12.2518393

18 December 2018 Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips

Zdeněk Pilát, Martin Kizovský, Jan Ježek, Stanislav Krátký, Jaroslav Sobota, Martin Šiler , Ota Samek , Tomáš Buryška , Pavel Vaňáček , Jiří Damborský , Zbyněk Prokop , Pavel Zemánek

Author Affiliations +

Proceedings Volume 10976, 21st Czech-Polish-Slovak Optical Conference on Wave and Quantum Aspects of Contemporary Optics; 1097619 (2018) https://doi.org/10.1117/12.2518393
Event: 21st Czech-Polish-Slovak Optical Conference on Wave and Quantum Aspects of Contemporary Optics, 2018, Lednice, Czech Republic

Abstract

Optofluidics, a research discipline combining optics and microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples, e.g. for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we have developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.

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Zdeněk Pilát, Martin Kizovský, Jan Ježek, Stanislav Krátký, Jaroslav Sobota, Martin Šiler , Ota Samek , Tomáš Buryška , Pavel Vaňáček , Jiří Damborský , Zbyněk Prokop , and Pavel Zemánek "Surface-enhanced Raman spectroscopy of chloroalkanes in microfluidic chips", Proc. SPIE 10976, 21st Czech-Polish-Slovak Optical Conference on Wave and Quantum Aspects of Contemporary Optics, 1097619 (18 December 2018); https://doi.org/10.1117/12.2518393

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KEYWORDS

Surface enhanced Raman spectroscopy

Raman spectroscopy

Microfluidics

Calibration

Chemical analysis

Molecules

Analytical research

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