Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation)

Imran Rizvi; Girgis Obaid; Shubhankar Nath; Mustafa K. Ruhi; Kaitlin Moore; Shazia Bano; David Kessel; Tayyaba Hasan

doi:10.1117/12.2525889

14 August 2019 Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation)

Imran Rizvi, Girgis Obaid, Shubhankar Nath, Mustafa K. Ruhi, Kaitlin Moore, Shazia Bano, David Kessel, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110702D (2019) https://doi.org/10.1117/12.2525889
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Exploiting differences in photosensitizer (PS) localization and mechanisms of action with sequential or simultaneous activation protocols has been shown to improve photodynamic therapy (PDT) efficacy. Various sub-cellular, cellular and stromal components can be targeted, causing selective photodamage. Previous reports have shown that rationally targeting non-overlapping tumor compartments or sub-cellular sites considerably enhances outcomes from PDT. The current presentation describes the benefits of simultaneously targeting lysosomes and mitochondria/endoplasmic reticulum using lipid-anchored and entrapped liposomal preparations of benzoporphyrin derivative, respectively, with an emphasis on results in 3D models of ovarian cancer.

Conference Presentation

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Imran Rizvi, Girgis Obaid, Shubhankar Nath, Mustafa K. Ruhi, Kaitlin Moore, Shazia Bano, David Kessel, and Tayyaba Hasan "Targeted PDT-based combinations for cancer: sub-cellular sites and cytotoxic mechanisms (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110702D (14 August 2019); https://doi.org/10.1117/12.2525889

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