Low-cost smartphone-based dosimeter for individualization of PDT treatment planning for protoporphyrin IX based skin cancer treatment (Conference Presentation)

Alberto J. Ruiz; Ethan P. M. LaRochelle; M. Shane Chapman; Brian W. Pogue

doi:10.1117/12.2528176

14 August 2019 Low-cost smartphone-based dosimeter for individualization of PDT treatment planning for protoporphyrin IX based skin cancer treatment (Conference Presentation)

Alberto J. Ruiz, Ethan P. M. LaRochelle, M. Shane Chapman, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 1107058 (2019) https://doi.org/10.1117/12.2528176
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

The development of low-cost diagnostic tools is essential for translation into various clinical and low-resource settings. Current advances in solid-state lighting, smart-phone capabilities, and 3D printing provide an ideal environment for the development of low-cost imagers for point-of-care diagnostic applications. Protoporphyrin IX (PpIX) based photodynamic therapy (PDT) for actinic keratosis (AK) and non-melanoma skin cancers (NMSC) is widespread, yet no diagnostic point-of-care tools are commonly used to account for the heterogeneity of PpIX accumulation between patients and between lesions. These heterogeneities are correlated with treatment outcomes, such that PpIX dosimetry can provide guidance in PDT and can be used to direct critical decisions about treatment time, retreatment, or further skin preparation. Here, we report on a low-cost smart-phone based dosimetry system designed for use in individualized PDT treatment planning. This hand-held dosimetry system uses an iPhone 6s smartphone alongside a custom app for streamlined image capture and analysis, custom LED board and electronics for PpIX excitation, and a 3D printed base for system integration and measurement standardization. The system has been tested on mice incubated with Ameluz for 10-400 minutes, imaging every 10 minutes. The images showed monotonic response over time with saturation occurring around 3hrs. Linearity of PpIX vs. measured fluorescence was confirmed with 1% intralipid phantom imaging, with a lowest detectable level of 0.05 μM and highest non-saturated level of 4 μM. With the data to date confirming the viability of the system to measure the production of PpIX relevant for skin PDT, preparations for human clinical imaging are underway.

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Alberto J. Ruiz, Ethan P. M. LaRochelle, M. Shane Chapman, and Brian W. Pogue "Low-cost smartphone-based dosimeter for individualization of PDT treatment planning for protoporphyrin IX based skin cancer treatment (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 1107058 (14 August 2019); https://doi.org/10.1117/12.2528176

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KEYWORDS

Photodynamic therapy

Imaging systems

Skin cancer

Diagnostics

Image analysis

Point-of-care devices

Skin

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