Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy

C. Credi; O. Bibikova; C. Dallari; B. Tiribilli; F. Ratto; S. Centi; R. Pini; V. Artyushenko; R. Cicchi; Francesco S. Pavone

doi:10.1117/12.2526929

22 July 2019 Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy

C. Credi, O. Bibikova, C. Dallari, B. Tiribilli, F. Ratto, S. Centi, R. Pini, V. Artyushenko, R. Cicchi, Francesco S. Pavone

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110750V (2019) https://doi.org/10.1117/12.2526929
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Optical detection techniques based on surface enhanced Raman spectroscopy (SERS) can provide relevant information on molecular and protein composition of biological samples, thus enabling to discriminate between physiological and pathological conditions. With the attempt to develop point-of-impact diagnostics devices, in this study we combine lowcost fabrication processes with surface functionalization strategies for the fabrication of SERS-active polymeric substrates engineered to selectively detect specific biomarkers. By reversibly coupling these devices with the distal end of portable Raman instruments, SERS measurements could be potentially implemented for the early diagnosis of widespread pathologies by SERS analysis of liquid biopsies.

Citation Download Citation

C. Credi, O. Bibikova, C. Dallari, B. Tiribilli, F. Ratto, S. Centi, R. Pini, V. Artyushenko, R. Cicchi, and Francesco S. Pavone "Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy ", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750V (22 July 2019); https://doi.org/10.1117/12.2526929

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