Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

M. Mehdi Seyedebrahimi; Miguel A. Pleitez; Pouyan Mohajerani; Vasilis Ntziachristos

doi:10.1117/12.2531625

19 July 2019 Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR

M. Mehdi Seyedebrahimi, Miguel A. Pleitez, Pouyan Mohajerani, Vasilis Ntziachristos

Proceedings Volume 11077, Opto-Acoustic Methods and Applications in Biophotonics IV; 110771H (2019) https://doi.org/10.1117/12.2531625
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.

Citation Download Citation

M. Mehdi Seyedebrahimi, Miguel A. Pleitez, Pouyan Mohajerani, and Vasilis Ntziachristos "Non-invasive in-vivo sensing of metabolites with a novel optoacoustic spectroscope in the SWIR", Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 110771H (19 July 2019); https://doi.org/10.1117/12.2531625

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KEYWORDS

In vivo imaging

Optoacoustics

Signal to noise ratio

Spectroscopy

Short wave infrared radiation

Tissue optics

Light scattering

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