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6 March 2020 Quantification of skin reactivity after microneedle provocation using spatial frequency domain spectroscopy (Conference Presentation)
Hanna Jonasson, David Muller, Joakim Henricson, Chris Anderson, Rolf Saager
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Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 1121104 (2020) https://doi.org/10.1117/12.2542011
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Micro-projection array patches (MAPs) are an alternative approach to deliver vaccine without using needles and syringe. MAPs achieve improved vaccination efficiency by introducing a microtrauma in the skin, but a comprehensive understanding of all mechanisms behind this response remains elusive. Spatial frequency domain spectroscopy (SFDS) was used to quantify skin reactivity. This optical technique enables characterization of the skin response by identifying (1) functional tissue parameters, (2) changes in tissue structure and (3) measures of tissue damage. In a preliminary investigation, measurements were performed on 12 subjects in whom the MAP was applied on the lower forearm.
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Hanna Jonasson, David Muller, Joakim Henricson, Chris Anderson, and Rolf Saager "Quantification of skin reactivity after microneedle provocation using spatial frequency domain spectroscopy (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 1121104 (6 March 2020); https://doi.org/10.1117/12.2542011
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KEYWORDS
Skin
Tissue optics
Spectroscopy
Light scattering
Tissues
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