Dual modality multiphoton-OCT flexible endomicroscope with an integrated electromagnetic z-actuator for optical field-of-view switching and a piezo-fiber-scanner for image acquisition

Bernhard Messerschmidt; Gregor Matz; Sven Flämig; Karl Reichwald; Ekaterina Pshenay-Severin; Andreas Kamm; Claudia Reinlein; Teresa Kopf; Beatrice Korn; Karsten Kühnert; David Vasquez; Marianne Heilmann; Thomas Frank; Thomas Sattel; Tom Ströhla; Xiang Lu; Herbert Gross

doi:10.1117/12.2543382

19 February 2020 Dual modality multiphoton-OCT flexible endomicroscope with an integrated electromagnetic z-actuator for optical field-of-view switching and a piezo-fiber-scanner for image acquisition

Bernhard Messerschmidt, Gregor Matz, Sven Flämig, Karl Reichwald, Ekaterina Pshenay-Severin, Andreas Kamm, Claudia Reinlein, Teresa Kopf, Beatrice Korn, Karsten Kühnert, David Vasquez, Marianne Heilmann, Thomas Frank, Thomas Sattel, Tom Ströhla, Xiang Lu, Herbert Gross

Author Affiliations +

Proceedings Volume 11214, Endoscopic Microscopy XV; 112140X (2020) https://doi.org/10.1117/12.2543382
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

A miniature endomicroscope is presented that combines a large field-of-view (up to 1.7 mm) for OCT-imaging and a high-resolution mode with 360 μm field-of-view (NA = 0.5) for multi-photon fluorescence or OCT imaging. The 4.7x magnification variation is achieved by the axial positioning of an inner micro-optical lens group using an integrated electro-magnetic z-actuator. A reverse fiber-optic piezotube-scanner with minimized length is employed for the image acquisition by resonant spiral scanning. With the probe diameter of 2.7 mm and a rigid length of about 60 mm, the approach may pave the way to clinical applications of these two modalities in a single probe.

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Bernhard Messerschmidt, Gregor Matz, Sven Flämig, Karl Reichwald, Ekaterina Pshenay-Severin, Andreas Kamm, Claudia Reinlein, Teresa Kopf, Beatrice Korn, Karsten Kühnert, David Vasquez, Marianne Heilmann, Thomas Frank, Thomas Sattel, Tom Ströhla, Xiang Lu, and Herbert Gross "Dual modality multiphoton-OCT flexible endomicroscope with an integrated electromagnetic z-actuator for optical field-of-view switching and a piezo-fiber-scanner for image acquisition", Proc. SPIE 11214, Endoscopic Microscopy XV, 112140X (19 February 2020); https://doi.org/10.1117/12.2543382

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KEYWORDS

Luminescence

Scanners

Zoom lenses

Cladding

Optical coherence tomography

Switching

Tissue optics

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