Clinical implementation of model-based dose planning for indoor daylight photodynamic therapy of skin (Conference Presentation)

Ethan Philip M. LaRochelle; Alberto J. Ruiz; M. Shane Chapman; Edward V. Maytin; Tayyaba Hasan; Brian W. Pogue

doi:10.1117/12.2543536

10 March 2020 Clinical implementation of model-based dose planning for indoor daylight photodynamic therapy of skin (Conference Presentation)

Ethan Philip M. LaRochelle, Alberto J. Ruiz, M. Shane Chapman, Edward V. Maytin, Tayyaba Hasan, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 1122006 (2020) https://doi.org/10.1117/12.2543536
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In recent years much work has been done to show treatment efficacy using daylight as the activation mechanism of PpIX-based PDT for non-melanoma skin cancers and pre-cancerous actinic keratosis. Many previous studies assume sufficient fluence is delivered during a 2-3 hour period, but fail to consider shifts in the UV spectral composition throughout the day and transient weather conditions. Using a model-based approach we have developed a dose planning application to provide clinicians with information regarding minimum necessary treatment times. Clinical photobleaching data comparing indoor daylight and conventional red-light PDT have been collected to test the viability of this model.

Conference Presentation

Citation Download Citation

Ethan Philip M. LaRochelle, Alberto J. Ruiz, M. Shane Chapman, Edward V. Maytin, Tayyaba Hasan, and Brian W. Pogue "Clinical implementation of model-based dose planning for indoor daylight photodynamic therapy of skin (Conference Presentation)", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122006 (10 March 2020); https://doi.org/10.1117/12.2543536

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