Surgery remains the primary method of care for multiple types of solid cancer. The goal of surgical oncology is to remove all tumorous tissue from the body. Frozen sectioning is commonly used during surgery to assess margin status. However, this method can be unreliable as the slides can be difficult to interpret. Using a recently reported imaging modality, Photoacoustic Remote Sensing (PARS), we present the first in human non-contact histology-like imaging in reflection mode. Cellular morphology alongside blood vessels are imaged in the human breast, gastrointestinal, and skin tissues. These images then compared with conventional hematoxylin and eosin-stained samples.
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