Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)

Eno Hysi; Muhannad N. Fadhel; Anoja Giles; Yanjie Wang; Joseph A. Sebastian; Gregory J. Czarnota; Agata A. Exner; Michael C. Kolios

doi:10.1117/12.2544302

20 April 2020 Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)

Eno Hysi, Muhannad N. Fadhel, Anoja Giles, Yanjie Wang, Joseph A. Sebastian, Gregory J. Czarnota, Agata A. Exner, Michael C. Kolios

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124029 (2020) https://doi.org/10.1117/12.2544302
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this work, we examine the potential of photoacoustic imaging for understanding the biophysical mechanism of nanobubble and microbubble-based vascular disrupting therapies. We present for the first time, a direct in-vivo comparison between sub-micron nanobubbles and the commercially available microbubbles. Our results show that PA imaging of tumor oxygenation is capable of measuring the nanobubble-induced almost 40% cell death as a result of vascular disruption.

Conference Presentation

Citation Download Citation

Eno Hysi, Muhannad N. Fadhel, Anoja Giles, Yanjie Wang, Joseph A. Sebastian, Gregory J. Czarnota, Agata A. Exner, and Michael C. Kolios "Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124029 (20 April 2020); https://doi.org/10.1117/12.2544302

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