Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)

Joel W. Y. Tan; Jeff Folz; Raoul Kopelman; Xueding Wang

doi:10.1117/12.2545205

20 April 2020 Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)

Joel W. Y. Tan, Jeff Folz, Raoul Kopelman, Xueding Wang

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112402B (2020) https://doi.org/10.1117/12.2545205
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Recently, Eil et al. showed that tumors with necrotic cores had elevated K+ concentrations due to the release of K+ by necrosis, which acts to suppress T-cell function by high extracellular K+ concentration. These findings demonstrate the importance of developing a tool for imaging K+ distributions. Here, we demonstrate K+ nanosensor-enabled photoacoustic imaging for measuring K+ levels in vivo. The nanosensor is an in-house synthesized optical contrast agent that is sensitive to K+ levels within biological ranges. The use of this K+ nanosensor, combined with multi-spectral photoacoustic imaging, allowed measurement of K+ levels in vivo.

Conference Presentation

Citation Download Citation

Joel W. Y. Tan, Jeff Folz, Raoul Kopelman, and Xueding Wang "Nanosensor-enabled in vivo photoacoustic potassium imaging (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112402B (20 April 2020); https://doi.org/10.1117/12.2545205

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