Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity (Conference Presentation)

Nichaluk Leartprapun; Yuechuan Lin; Steven G. Adie

doi:10.1117/12.2546372

9 March 2020 Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity (Conference Presentation)

Nichaluk Leartprapun, Yuechuan Lin, Steven G. Adie

Author Affiliations +

Proceedings Volume 11242, Optical Elastography and Tissue Biomechanics VII; 1124203 (2020) https://doi.org/10.1117/12.2546372
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Photonic force optical coherence elastography (PF-OCE) is a new approach for volumetric characterization of microscopic mechanical properties of soft materials. PF-OCE utilizes harmonically modulated optical radiation pressure to exert localized mechanical excitation on individual microbeads embedded in viscoelastic media. We present microrheological quantification of complex shear modulus in polyacrylamide gels with PF OCE. Spectroscopic measurements over a frequency range spanning 1 Hz to 7 kHz revealed rich frequency-dependent microstructural dynamics of entangled polymer networks across multiple microrheological regimes. PF-OCE provides an all-optical approach to quantitative three-dimensional mechanical microscopy and broadband spectroscopic microrheological studies of soft materials.

Conference Presentation

Citation Download Citation

Nichaluk Leartprapun, Yuechuan Lin, and Steven G. Adie "Photonic force optical coherence elastography for spectroscopic microrheological quantification of hydrogel viscoelasticity (Conference Presentation)", Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 1124203 (9 March 2020); https://doi.org/10.1117/12.2546372

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KEYWORDS

Spectroscopy

Coherence (optics)

Elastography

Optical coherence tomography

Interferometry

Microscopy

Modulation

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