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10 March 2020 Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering (Conference Presentation)
Walker Peterson, Kotaro Hiramatsu, Keisuke Goda
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Proceedings Volume 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020; 1125107 (2020) https://doi.org/10.1117/12.2544091
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
By virtue of its chemical specificity and label-free nature, Raman spectroscopy is a ubiquitous tool in analytical chemistry which has recently found increasing interest in biology and medicine, as technical improvements steadily enable applications. In particular, the low-frequency region of the Raman spectrum, which contains rich information about intermolecular interactions and higher-order structure, has promise for biological applications. However, detection of low-frequency modes remains a challenge with conventional techniques for Raman spectroscopy. Here, we propose and experimentally demonstrate Sagnac-enhanced impulsive stimulated Raman scattering (SE-ISRS), a method for time-domain Raman spectroscopy that provides highly sensitive low-frequency Raman spectra at all probe frequencies.
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Walker Peterson, Kotaro Hiramatsu, and Keisuke Goda "Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering (Conference Presentation)", Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 1125107 (10 March 2020); https://doi.org/10.1117/12.2544091
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KEYWORDS
Raman spectroscopy
Raman scattering
Spectroscopy
Chemical analysis
Intelligence systems
Signal to noise ratio
Biological research
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