High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)

Trevor Mitcham; Dmitry Nevozhay; Aaron Schwartz-Duval; Stephen Lai; Konstantin Sokolov; Richard Bouchard

doi:10.1117/12.2549324

27 March 2020 High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)

Trevor Mitcham, Dmitry Nevozhay, Aaron Schwartz-Duval, Stephen Lai, Konstantin Sokolov, Richard Bouchard

Author Affiliations +

Proceedings Volume 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography; 113190Q (2020) https://doi.org/10.1117/12.2549324
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

Current molecular imaging modalities face barriers to clinical implementation, providing a need for an improved clinical molecular imaging approach. We hypothesize that EGFR-targeted perfluorocarbon nanodroplets can label metastatic cells; they can then be activated (i.e., converted to a microbubble) and imaged using ultrasound in order to provide a molecular contrast agent that can inform treatment. Pulse sequences were developed for the Verasonics Vantage 128 system to activate and image dodecafluoropentane and dodecafluorohexane nanodroplets. Dodecafluoropentane nanodroplets provided 28-dB enhancement when imaged with pulse-inversion US in a tissue-mimicking environment, while dodecafluorohexane nanodroplets showed activation and subsequent recondensation, allowing for super-resolution imaging.

Conference Presentation

Citation Download Citation

Trevor Mitcham, Dmitry Nevozhay, Aaron Schwartz-Duval, Stephen Lai, Konstantin Sokolov, and Richard Bouchard "High-frequency ultrasound imaging of targeted, acoustically activated high-contrast Perfluorocarbon Nanodroplets (Conference Presentation)", Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography, 113190Q (27 March 2020); https://doi.org/10.1117/12.2549324

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Nanodroplets

Ultrasonography

Imaging systems

Molecular imaging

Super resolution

Tissues

Visualization

Show All Keywords

Keywords/Phrases

Search In:

Publication Years