Phantoms of optical and stress-related properties of cerebral arteries with aneurysms for intravascular optical coherence tomography

A. Yu. Potlov; S. V. Frolov; T. A. Frolova; S. G. Proskurin

doi:10.1117/12.2563854

9 April 2020 Phantoms of optical and stress-related properties of cerebral arteries with aneurysms for intravascular optical coherence tomography

A. Yu. Potlov, S. V. Frolov, T. A. Frolova, S. G. Proskurin

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114571Q (2020) https://doi.org/10.1117/12.2563854
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

A method for tissue-like phantoms preparation for cerebral arteries with aneurysms is presented. Magnetic resonance angiography (MRA) images are used as a source of structural information about the geometry of the simulated cerebral arteries and surrounding brain tissue. Blood vessels were reconstructed as hollow structures with three-layer walls. The inner layer corresponds to the intima of the real vessel, its middle layer - media, and the outer layer - adventitia. The basis for the reconstruction of the first layer of hollow structures and mold for casting surrounding brain tissue were 3D printed. Hollow structures were reconstructed applying layer-by-layer method with use of two-component transparent silicone gel with a variable mass fraction of two components, A and B. Variation the mass fraction of the components and thickness for each layer allows achieving the necessary stress-related properties. Equivalence to the real structure of the cerebral arteries and optical properties were achieved by variation of mass fraction of the additives for each layer matrix. A powder of titanium dioxide was used as scattering particles and a special gel colourant for silicone was applied as an absorbing agent. Hollow structures were added in the mold for casting surrounding brain tissue simulator, so that their geometrical arrangement corresponds to associated blood vessels. The proximal and distal ends of hollow structures are equipped with forked catheters.

Citation Download Citation

A. Yu. Potlov, S. V. Frolov, T. A. Frolova, and S. G. Proskurin "Phantoms of optical and stress-related properties of cerebral arteries with aneurysms for intravascular optical coherence tomography", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114571Q (9 April 2020); https://doi.org/10.1117/12.2563854

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KEYWORDS

Tissues

Blood vessels

Optical coherence tomography

Silicon

Tissue optics

Liquids

Arteries

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