Calcium activity in a sponge astrocyte model with AVF-parameter control

Darya V. Verveyko; Andrey Yu. Verisokin; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2564439

9 April 2020 Calcium activity in a sponge astrocyte model with AVF-parameter control

Darya V. Verveyko, Andrey Yu. Verisokin, Dmitry E. Postnov, Alexey R. Brazhe

Proceedings Volume 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 114590O (2020) https://doi.org/10.1117/12.2564439
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

We simulate the formation and dynamics of calcium waves in a distributed astrocyte network. We take into account volume effects induced by the real morphology of an astrocyte cell. Astrocytes are sponge-like structures which do not occupy the entire volume of its compartment: astrocyte leaflets are surrounded by the neuropil. We introduce the astrocyte volume fraction (AVF) parameter which shows the part of the 2D template occupied by an astrocyte versus neuropil and correlates with this ratio in a real 3D structure. To describe the difference in the processes in branchlets and leaflets of an astrocyte and the continuous transition between them we use the surface-to-volume ratio (SVR) parameter.

Citation Download Citation

Darya V. Verveyko, Andrey Yu. Verisokin, Dmitry E. Postnov, and Alexey R. Brazhe "Calcium activity in a sponge astrocyte model with AVF-parameter control", Proc. SPIE 11459, Saratov Fall Meeting 2019: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 114590O (9 April 2020); https://doi.org/10.1117/12.2564439

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