Making sense of brain activity in response to optical manipulation in-vivo in Zebrafish

Itia A. Favre-Bulle; Michael Taylor; Gilles Vanwalleghem; Halina Rubinsztein-Dunlop; Ethan Scott

doi:10.1117/12.2571321

22 August 2020 Making sense of brain activity in response to optical manipulation in-vivo in Zebrafish

Itia A. Favre-Bulle, Michael Taylor, Gilles Vanwalleghem, Halina Rubinsztein-Dunlop, Ethan Scott

Proceedings Volume 11463, Optical Trapping and Optical Micromanipulation XVII; 114631K (2020) https://doi.org/10.1117/12.2571321
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

Making sense of the brain network and functions from individual neuronal activity is a challenging task. We developed a data analysis pipeline, combining unsupervised learning and supervised learning methods to reveal some of the intricacies of brain function in zebrafish. We were interested in particular to apply it to the senses of hearing, and balance. Using Optical Tweezers, we manipulated optically and individually each of the four ear stones which reside in the inner ear. Consequently, we simulated sound and acceleration in an alive zebrafish with laser beams. I will present the study of behaviour and neural responses to these stimulations.

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Citation Download Citation

Itia A. Favre-Bulle, Michael Taylor, Gilles Vanwalleghem, Halina Rubinsztein-Dunlop, and Ethan Scott "Making sense of brain activity in response to optical manipulation in-vivo in Zebrafish", Proc. SPIE 11463, Optical Trapping and Optical Micromanipulation XVII, 114631K (22 August 2020); https://doi.org/10.1117/12.2571321

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