utilizing upconverting nanoparticles as optical pH sensors

Eric Rappeport; Conrad Corbella Bagot; Ananda Das; Taleb Ba Tis; Wounjhang Park

doi:10.1117/12.2568952

21 August 2020 utilizing upconverting nanoparticles as optical pH sensors

Eric Rappeport, Conrad Corbella Bagot, Ananda Das, Taleb Ba Tis, Wounjhang Park

Proceedings Volume 11467, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVII; 1146710 (2020) https://doi.org/10.1117/12.2568952
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Abstract

The ability to measure pH on a cellular scale has a wide range of potential use in biology and medicine. In this paper, we describe our work on creating a nanoscale pH sensor via the conjugation of upconverting nanoparticles (UCNPs) with a fluorescent dye. We will the explain the origin of the optical pH sensitivity, the conjugation procedure, as well as the various measurement techniques used to confirm the sensitivity. These nanoparticles allow simple optical sensing of pH without complicated intensity calibration process and could thus be widely applicable to many complex biological systems.

Conference Presentation

Citation Download Citation

Eric Rappeport, Conrad Corbella Bagot, Ananda Das, Taleb Ba Tis, and Wounjhang Park "utilizing upconverting nanoparticles as optical pH sensors", Proc. SPIE 11467, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVII, 1146710 (21 August 2020); https://doi.org/10.1117/12.2568952

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