Acoustoelastic full-waveform inversion for transcranial ultrasound computed tomography

Patrick Marty; Christian Boehm; Andreas Fichtner

doi:10.1117/12.2581029

15 February 2021 Acoustoelastic full-waveform inversion for transcranial ultrasound computed tomography

Patrick Marty, Christian Boehm, Andreas Fichtner

Proceedings Volume 11602, Medical Imaging 2021: Ultrasonic Imaging and Tomography; 1160211 (2021) https://doi.org/10.1117/12.2581029
Event: SPIE Medical Imaging, 2021, Online Only

Abstract

Full-waveform inversion applied to ultrasound computed tomography is a promising technique to provide highresolution quantitative images of soft human tissues, which are otherwise difficult to illuminate by conventional ultrasound imaging. A particular challenge which arises within transcranial ultrasound is the imprint of the solid skull on the measured wavefield. We present an acoustoelastic approach to full-waveform inversion for transcranial ultrasound computed tomography that accurately accounts for the solid-fluid interactions along the skull-tissue interfaces. Using the spectral-element method on cubical meshes, we obtain a scalable and performant method to resolve such a coupled physical system. Moreover, since the volume of the skull is small compared to the entire simulation domain, solving a coupled system of the acoustoelastic wave equation increases the computational cost only by a small margin compared to the acoustic approximation. We perform an in silico forward and inverse modeling study that reveals significant coupling effects at the skull-tissue interfaces when considering the skull as an elastic medium as opposed to an acoustic medium. Applying full-waveform inversion to a set of synthetically generated acoustoelastic forward data allows for favorable reconstructions to be achieved when considering an acoustoelastic prior model of the skull.

Conference Presentation

Citation Download Citation

Patrick Marty, Christian Boehm, and Andreas Fichtner "Acoustoelastic full-waveform inversion for transcranial ultrasound computed tomography", Proc. SPIE 11602, Medical Imaging 2021: Ultrasonic Imaging and Tomography, 1160211 (15 February 2021); https://doi.org/10.1117/12.2581029

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