Surpassing the resolution limit of adaptive optics imaging in the living human eye by combining annular pupil illumination with sub-Airy disk confocal pinhole detection

Rongwen Lu; Nancy Aguilera; Tao Liu; Jianfei Liu; John P. Giannini; Joanne Li; Andrew J. Bower; Alfredo Dubra; Johnny Tam

doi:10.1117/12.2583069

5 March 2021 Surpassing the resolution limit of adaptive optics imaging in the living human eye by combining annular pupil illumination with sub-Airy disk confocal pinhole detection

Rongwen Lu, Nancy Aguilera, Tao Liu, Jianfei Liu, John P. Giannini, Joanne Li, Andrew J. Bower, Alfredo Dubra, Johnny Tam

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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230B (2021) https://doi.org/10.1117/12.2583069
Event: SPIE BiOS, 2021, Online Only

Abstract

High-resolution imaging is essential for understanding retinal diseases. Adaptive optics scanning light ophthalmoscopy (AOSLO) achieves cellular-level resolution through correction of the optical aberrations of the eye. However, the resolution of AOSLO is still limited by the diffraction of light. Here, we combine annular pupil illumination with sub-Airy disk confocal pinhole detection to surpass the diffraction limit. With the improved resolution, both rod photoreceptor and foveal cone mosaics were more readily identifiable in the living human eye.

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Rongwen Lu, Nancy Aguilera, Tao Liu, Jianfei Liu, John P. Giannini, Joanne Li, Andrew J. Bower, Alfredo Dubra, and Johnny Tam "Surpassing the resolution limit of adaptive optics imaging in the living human eye by combining annular pupil illumination with sub-Airy disk confocal pinhole detection", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230B (5 March 2021); https://doi.org/10.1117/12.2583069

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KEYWORDS

Confocal microscopy

Adaptive optics

Eye

Image resolution

Cones

Rods

3D metrology

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