PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Many topically applied drugs are naturally fluorescent, but quantifying their uptake into skin via fluorescence emission is complicated by both weak fluorescence and often-overwhelming skin autofluorescence. Fluorescence lifetime imaging microscopy (FLIM) has been found capable of identifying and separating the fluorescence of multiple drugs from skin autofluorescence via their different spectral and lifetime properties. This investigation was focused on combining epi-fluorescence microscopy with deep learning for the quantification of naturally fluorescent topically applied drugs. This combination of deep learning and fluorescence imaging may allow for straightforward relative quantification of fluorescent drugs in tissue using only simple, readily available imaging tools.
Conor L. Evans,Maiko Hermsmeier, andKin Chan
"Deep learning based quantification of cutaneous drug uptake from standard epi-fluorescence microscopy", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 116240J (7 March 2021); https://doi.org/10.1117/12.2577350
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Conor L. Evans, Maiko Hermsmeier, Kin Chan, "Deep learning based quantification of cutaneous drug uptake from standard epi-fluorescence microscopy," Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 116240J (7 March 2021); https://doi.org/10.1117/12.2577350