Mesoscopic imaging of functional connectivity in mouse cortex

Qinggong Tang; Vassiliy Tsytsarev; Feng Yan; Chen Wang; Reha S. Erzurumlu; Yu Chen

doi:10.1117/12.2576577

5 March 2021 Mesoscopic imaging of functional connectivity in mouse cortex

Qinggong Tang, Vassiliy Tsytsarev, Feng Yan, Chen Wang, Reha S. Erzurumlu, Yu Chen

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162926 (2021) https://doi.org/10.1117/12.2576577
Event: SPIE BiOS, 2021, Online Only

Abstract

Cellular layering is a hallmark of the mammalian neocortex. A key challenge in studying circuit function within the neocortex is to understand the spatial and temporal patterns of information flow between different columns and layers. In the paper, a mesoscopic functional imaging method for neural activities in mouse cortex in vivo was developed and demonstrated. We demonstrated the depth-resolved capability of 3D mesoscopic imaging by photostimulating the layer 5 neurons in Thy1-ChR2-YFP transgenic mice and further recorded the layer-specific functional projections between primary somatosensory cortex and primary motor cortex in vivo, following single whisker deflection.

Conference Presentation

Citation Download Citation

Qinggong Tang, Vassiliy Tsytsarev, Feng Yan, Chen Wang, Reha S. Erzurumlu, and Yu Chen "Mesoscopic imaging of functional connectivity in mouse cortex", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162926 (5 March 2021); https://doi.org/10.1117/12.2576577

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