Diffusion-based probe for low liquid sampling rate for biomedical application

H. Landari; Y. Messaddeq; A. Miled

doi:10.1117/12.2577826

5 March 2021 Diffusion-based probe for low liquid sampling rate for biomedical application

H. Landari, Y. Messaddeq, A. Miled

Proceedings Volume 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX; 116370F (2021) https://doi.org/10.1117/12.2577826
Event: SPIE BiOS, 2021, Online Only

Abstract

In this work, we present numerical simulation results of a designed microfluidic probe for liquid extraction and local drug delivery. The designed probe ensures three different operating modes which are, direct sampling, direct drug delivery and diffusion based sampling. The reported results of finite elements simulation shows that using diffusion phenomena a molecular sample can be extracted from an aqueous sample with this probe. In addition, the best operational parameters of the probe were a tilt angle of 25° and an inlet/outlet velocity of 2 μm/s in order to get the higher concentration of extracted molecule in the buffer solution.

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Citation Download Citation

H. Landari, Y. Messaddeq, and A. Miled "Diffusion-based probe for low liquid sampling rate for biomedical application", Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370F (5 March 2021); https://doi.org/10.1117/12.2577826

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