Significant research has been done to develop functional bio-inspired nano-architectures for photonic, biomedical and energy storage applications. Among these, peptide nanostructures are the prime candidates with unique optical properties, like the wide optical transparency, high refractive index contrast, and optical nonlinearity. In this work, a linear aromatic diphenylalanine peptide, which is the core motif of Alzheimer-amyloid protein, is self-assembled into open-end hexagonal microtubes. The waveguiding aspects of the tubes are studied with high NA objectives acting as a major optical component to couple light into one of the ends of the tubes. Our study tells that the micro-waveguide’s performance with chromatically aberrated i.e uncorrected objective is far better than the corrected one giving a higher dynamical range, higher signal-to-noise ratio, and higher guided peak resolution, thus making it more suitable for fine measurements. The experimental results are verified using the finite difference time domain method. The higher resolution, higher scan depth, and color selectivity with the aberrated objectives indicate deploying these waveguides in biosensing and other applications.
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