Deep tissue imaging by optical coherence tomography / microscopy at Optical Window III

Norihiko Nishizawa; Masahito Yamanaka

doi:10.1117/12.2615666

27 October 2021 Deep tissue imaging by optical coherence tomography / microscopy at Optical Window III

Proceedings Volume 11925, Biomedical Imaging and Sensing Conference 2021; 119250N (2021) https://doi.org/10.1117/12.2615666
Event: SPIE Technologies and Applications of Structured Light, 2021, Online, Japan

Abstract

Optical coherence tomography (OCT) is a non-invasive cross-sectional imaging technique with micrometer resolution. We have been investigating ultrahigh-resolution (UHR)-OCT using supercontinuum. The characteristics of OCT imaging depend on the optical wavelength used. In order to investigate the wavelength dependence of UHR-OCT, the wideband, high-power, low-noise supercontinua were generated at wavelengths of 0.8, 1.1, 1.3, and 1.7 um based on ultrashort pulses and nonlinear fibers. The wavelength dependence of OCT imaging was examined quantitatively using biological phantoms and rat lung tissue. Then we developed UHR-OCT and optical coherence microscopy (OCM) at 1.7 um, which is called as “Optical Window III”. The high-resolution and high-penetration imaging of mouse brain was demonstrated.

Citation Download Citation

Norihiko Nishizawa and Masahito Yamanaka "Deep tissue imaging by optical coherence tomography / microscopy at Optical Window III", Proc. SPIE 11925, Biomedical Imaging and Sensing Conference 2021, 119250N (27 October 2021); https://doi.org/10.1117/12.2615666

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