In vivo observation of allergic dermatitis of the animal model by optical coherence tomography

Masato Ohmi; Yuki Yoshida; Yoken Son; Kohji Abe

doi:10.1117/12.2609181

7 March 2022 In vivo observation of allergic dermatitis of the animal model by optical coherence tomography

Masato Ohmi, Yuki Yoshida, Yoken Son, Kohji Abe

Proceedings Volume 11934, Photonics in Dermatology and Plastic Surgery 2022; 119340K (2022) https://doi.org/10.1117/12.2609181
Event: SPIE BiOS, 2022, San Francisco, California, United States

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Abstract

In order to understand pathogenic mechanism of allergic dermatitis, it is important to find morphological changes of the internal structure of the skin by non-invasive imaging. Optical coherence tomography (OCT) is powerful tool for in vivo tomographic imaging of the internal microstructure in biological tissue. We propose in vivo observation of allergic skin of guinea pigs by OCT. As a result, epidermis thickening became evident as the days passing since Day 7, and the capillary vessel expansion was confirmed since Day 14; the process of inflammation development was successfully observed.

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Masato Ohmi, Yuki Yoshida, Yoken Son, and Kohji Abe "In vivo observation of allergic dermatitis of the animal model by optical coherence tomography", Proc. SPIE 11934, Photonics in Dermatology and Plastic Surgery 2022, 119340K (7 March 2022); https://doi.org/10.1117/12.2609181

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