Fiber optic laser light scattering measurement of ciliary function of the fallopian tube

Sheridan A. Halbert; Kap Lim; Wylie I. Lee

doi:10.1117/12.17566

1 July 1990 Fiber optic laser light scattering measurement of ciliary function of the fallopian tube

Sheridan A. Halbert, Kap Lim, Wylie I. Lee

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17566
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

A fiber-optic laser light-scattering system (FLS) for measuring ciliary function was evaluated by means of three sets of in vitro experiments. First, FLS performance was compared to that of a previously proven benchtop laser system (BLS). Using tissue excised from rabbit fallopian tubes, ciliary beat frequency (CBF) of each sample was measured with FLS and BLS. Paired CBF measurements showed excellent correlation between the two systems (r =0.93). Second, the FLS was used to evaluate the dependency of CBF on temperature (T) by using tissue sampies of rabbit oviductal fimbna. Regression analysis of CBF vs T showed a linear relationship over the range of 18-37°C for both individual samples (r =0.98) and pooled data from all experiments (r = 0.84). Fmally, the relalionship between CBF and ciliary ovum transport rate (TR) was tested by using T to modulate CBF of rabbit fimbria, in vitro. The relationship was linear over the range of CBF from 10 to 30 Hz (r2 = 0.83). At 37°C, CBF = 31±1 Hz, and TR = O.12±.02 mm/sec. equal to ovum transport rate in situ. The FLS is a valuable tool for characterizing ciliary activity and thus ovum transport function. Owing to the fact that ciliary dyskinesia resulting from disease of the fallopian tube is associated with infeitility, the FLS may be useful to acquire data important to the clinical evaluation of fallopian tube function and female infertility.

Citation Download Citation

Sheridan A. Halbert, Kap Lim, and Wylie I. Lee "Fiber optic laser light scattering measurement of ciliary function of the fallopian tube", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17566

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